Evaluation of non-invasive detection of blood glucose using OCT

XU Quan-sheng; FENG Shu; YE Da-tian

doi:10.3788/OPE.20101812.2688

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Evaluation of non-invasive detection of blood glucose using OCT

Article | 更新时间：2020-08-12

- Evaluation of non-invasive detection of blood glucose using OCT
- Optics and Precision Engineering Vol. 18, Issue 12, Pages: 2688-2694(2010)
- 作者机构：
  
  清华大学深圳研究生院生物医学工程研究中心, 广州深圳 518055
- 作者简介：
- 基金信息：
- DOI：10.3788/OPE.20101812.2688
  CLC： TP391;R814.42
- Received：01 December 2009，
  
  Revised：12 March 2010，
  
  Published Online：25 December 2010，
  
  Published：25 December 2010
- 稿件说明：
移动端阅览
许全盛, 冯曙, 叶大田. 光学相干层析术无损检测血糖的测量效果评价[J]. 光学精密工程, 2010,18(12): 2688-2694

XU Quan-sheng, FENG Shu, YE Da-tian. Evaluation of non-invasive detection of blood glucose using OCT[J]. Editorial Office of Optics and Precision Engineering, 2010,18(12): 2688-2694
许全盛, 冯曙, 叶大田. 光学相干层析术无损检测血糖的测量效果评价[J]. 光学精密工程, 2010,18(12): 2688-2694 DOI： 10.3788/OPE.20101812.2688.

XU Quan-sheng, FENG Shu, YE Da-tian. Evaluation of non-invasive detection of blood glucose using OCT[J]. Editorial Office of Optics and Precision Engineering, 2010,18(12): 2688-2694 DOI： 10.3788/OPE.20101812.2688.

摘要

为改进现有光学相干层析术(OCT)无损检测血糖评价方法的不足

提出将OCT信号斜率相对变化量和相对标准误差相结合来评价测量结果

并同时得到血糖的理论测量精度。首先

分析了OCT系统共焦函数对测量结果的影响及OCT信号斜率相对误差的计算方法

然后

通过对3只新西兰白兔进行活体实验来评价OCT无损检测血糖的测量结果。在测量血糖引起的OCT信号斜率相对变化量的同时

对OCT信号斜率相对误差也进行了计算

从而获得血糖的理论测量精度。新西兰白兔活体实验表明

线性度较好的拟合区间下OCT信号斜率相对变化量和相对误差分别为(3.7%)/mmol和0.068

(3.4%)/mmol和0.026

(0.93%)/mmol和0.019

血糖理论测量精度分别为3.7 mmol

1.5 mmol和4.1 mmol。OCT信号斜率的相对变化量和相对标准误差相结合的评价方法能更有效地提高血糖理论测量精度

而且拟合区间越大

血糖的测量精度越高。

Abstract

To improve the evaluation method of non-invasive detection of blood glucose by Optical Coherence Tomography(OCT)

a method combining the relative variance of OCT signal slope with the relative standard error was presented to evaluate the measurement effect and to obtain the theoretical precision of blood glucose detection. Firstly

the effect of the OCT confocal function on the blood glucose detection and the computing method of the relative error of OCT signal slope were given. Then

the relative variance and standard error of the OCT signal slope via a vivo experiment on 3 New Zealand rabbits were carried out to evaluate the non-invasive detection of blood glucose. Obtained results indicate that the relative variance and standard error of OCT signal slope are (3.7 %)/mmol & 0.068

(3.4 %)/mmol & 0.026

(0.93 %)/mmol & 0.019

respectively

and the theoretical measuring precision of blood glucose detection are 3.7 mmol

1.5 mmol and 4.1 mmol

respectively. It concludes that the the evaluation method of combining the relative variance and standard error of OCT signal slope can greatly improve the theoretical measuring precision of blood glucose detection

and the larger the fitting interval is

the higher the measuring precision is.

关键词

Keywords

references

FENG S, YUAN K, YE D. Precision of glucose measurement in intralipid suspensions with optical coherence tomography [J]. SPIE, 2008:510-513.[2] 郑羽,李刚,张泰石,等. 采用特殊镀膜分束器的OCT系统性能分析[J]. 光学精密工程, 2006,14(6):1082-1087. ZHENG Y, LI G, ZHANG T, et al..Performance analysis of an optical coherence tomography system with special coating beam splitter [J]. Opt. Precision Eng., 2006,14(6):1082-1087. (in Chinese)[3] 李刚,张泰石,郑羽,等. 频域OCT的光学相移器的标定[J]. 光学精密工程,2008, 16(1):114-121. LI G, ZHANG T, ZHENG Y, et al.. Calibration of phase shifter in spectral domain OCT system [J]. Opt. Precision Eng., 2008,16(1):114-121. (in Chinese)[4] 郑羽,李刚,刘晶晶,等. 在CSOCT系统中抑制线性相移误差的校正算法[J]. 光学精密工程, 2007,15 (5):753-759. ZHENG Y, LI G, LIU J J, et al.. Correction algorithm of restriction of linear phase-shift in complex spectral OCT system [J]. Opt. Precision Eng., 2007,15(5):753-759. (in Chinese)[5] KINNUNEN M, MYLLYL R, JOKELA T, et al.. In vitro studies toward noninvasive glucose monitoring with optical coherence tomography [J]. Applied Optics, 2006,45(10):2251.[6] LARIN K, MOTAMEDI M, ASHITKOV T, et al.. Specificity of noninvasive blood glucose sensing using optical coherence tomography technique: a pilot study[J]. Physics in Medicine and Biology, 2003,48(10):1371.[7] LARIN K, ELEDRISI M, MOTAMEDI M, et al.. Noninvasive blood glucose monitoring with optical coherence tomography: a pilot study in human subjects [J]. Diabetes Care, 2002,25(12):2263.[8] LARIN K, ASHITKOV T, LARINA I, et al.. Optical coherence tomography and noninvasive blood glucose monitoring: a review [J].SPIE, 2004,5474:285.[9] FENG S, YUAN K, YE D. Effect of multiple scattering on measured signal losses using optical coherence tomography studied by monte carlo simulation [J]. International Journal of Innovative Computing, Information and Control, 2010,6(3):4249-4262.(in press)[10] KHOLODNYKH A, PETROVA I, LARIN K. Optimization of low coherence interferometry for quantitative analysis of tissue optical properties [J]. SPIE, 2002,4624:36.[11] KHOLODNYKH A, PETROVA I, MOTAMEDI M, et al.. Bifocal technique for accurate measurement of total attenuation coefficient in scattering media with OCT . Proceeding of the Second Joint EMBSBMES Conference Houston, TX, USA, 2002:2251.[12] FENG S, YUAN K, YE D. Efficient fitting range for scatter measurement with optical coherence tomography [J]. SPIE, 2009,7280(0M):1-7.[13] FENG S, YUAN K,YE D. Efficient fitting range for glucose measurement with optical coherence tomography [J]. Journal of Innovative Optical Health Sciences, 2009,2(1):107-115.

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