Interstitial fluid transdermal extraction tool based on microfluidics technology

YU Hai-xia; LI Da-chao; LIU Tong-kun; XU Ke-xin

doi:10.3788/OPE.20111903.0651

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Interstitial fluid transdermal extraction tool based on microfluidics technology

Article | 更新时间：2020-08-12

- Interstitial fluid transdermal extraction tool based on microfluidics technology
- Optics and Precision Engineering Vol. 19, Issue 3, Pages: 651-656(2011)
- 作者机构：
  
  天津大学精密仪器与光电子工程学院精密测试技术及仪器国家重点实验室,天津 300072
- 作者简介：
- 基金信息：
- DOI：10.3788/OPE.20111903.0651
  CLC： TH47;TH789
- Received：19 April 2010，
  
  Revised：24 July 2010，
  
  Published Online：22 March 2011，
  
  Published：22 March 2011
- 稿件说明：
移动端阅览
于海霞, 栗大超, 刘同坤, 徐可欣. 基于微流体技术的组织液透皮抽取装置[J]. 光学精密工程, 2011,19(3): 651-656

YU Hai-xia, LI Da-chao, LIU Tong-kun, XU Ke-xin. Interstitial fluid transdermal extraction tool based on microfluidics technology[J]. Editorial Office of Optics and Precision Engineering, 2011,19(3): 651-656
于海霞, 栗大超, 刘同坤, 徐可欣. 基于微流体技术的组织液透皮抽取装置[J]. 光学精密工程, 2011,19(3): 651-656 DOI： 10.3788/OPE.20111903.0651.

YU Hai-xia, LI Da-chao, LIU Tong-kun, XU Ke-xin. Interstitial fluid transdermal extraction tool based on microfluidics technology[J]. Editorial Office of Optics and Precision Engineering, 2011,19(3): 651-656 DOI： 10.3788/OPE.20111903.0651.

摘要

为了在连续血糖监测中实现微量组织液的透皮抽取和收集

采用微流体技术

利用聚二甲基硅氧烷(Polydimethylsiloxane

PDMS)设计加工了组织液透皮抽取装置。首先

采用模塑法加工得到组成装置的4层PDMS。接着

采用氧等离子体键合方法键合PDMS获得能够产生真空负压的文氏管

用于注入生理盐水、抽取组织液和收集组织液的腔体

控制流体传输的气动阀以及连接各部分的微管路4部分装置。然后

测量文氏管的输出负压和气动阀的关闭压强。最后

检验了装置抽取和收集组织液的功能实现情况。结果显示

将220 kPa(绝对压强)的氮气通入文氏管的输入端口

在文氏管的喉部端口获得了92 kPa(绝对压强)的真空负压。另外

只需低于65 kPa(相对压强)的压强就可以关闭采用PDMS薄膜加工的常开型气动阀。该装置可在气动阀的控制下

利用文氏管产生的真空负压

自动完成生理盐水的注入、组织液的抽取和收集。

Abstract

A microfluidic based Interstitial Fluid (ISF) transdermal extraction tool made from polydimethylsiloxane (PDMS) was designed to the application of continuous glucose monitoring. Four layers of PDMS fabricated by replica molding process were bonded together using oxygen plasma to construct the device

including a Venturi tube for vacuum generation

chambers for the introduction of ISF and normal saline solution

pneumatic valves for fluid control

and interconnected microchannels. Then

the output vacuum of Venturi tube and the close pressure of pneumatic valve were measured. Finally

the ISF extraction and collection function was tested. Results show that the vacuum pressure is used for fluid manipulation and a 92 kPa (absolute pressure) vacuum is achieved

when 220 kPa (absolute pressure) external pressure is applied to the Venturi tube. Moreover

the normally open pneumatic valves can be closed under the operating pressure less than 65 kPa (relative pressure). Under the control of pneumatic valves

the normal saline injection

ISF extraction and collection function of the tool are implemented by using the vacuum generated from the Venturi tube.

关键词

Keywords

references

KLONOFF D C. A review of continuous glucose monitoring technology [J]. Diabetes Technology & Therapeutics, 2005,7(5):770-775.[2] MITRAGOTRI S, COLEMAN M, KOST J, et al.. Analysis of ultrasonically extracted interstitial fluid as a predictor of blood glucose levels [J]. Journal of Applied Physiology, 2000,89(3):961-966.[3] TIESSEN R G, RHEMREV-BOOM M M, KORF J. Glucose gradient differences in subcutaneous tissue of healthy volunteers assessed with ultraslow microdialysis and a nanolitre glucose sensor [J]. Life Sciences, 2002, 70(21):2457-2466.[4] GARG S K, POTTS R O, ACKERMAN N R, et al.. Correlation of fingerstick blood glucose measurements with GlucoWatch biographer glucose results in young subjects with type 1 diabetes [J]. Diabetes Care, 1999,22(10):1708-1714.[5] GUERCI B, FLORIOT M, BOHME P, et al.. Clinical performance of CGMS in type 1 diabetic patients treated by continuous subcutaneous insulin infusion using insulin analogs [J]. Diabetes Care, 2003,26(3):582-589.[6] BURGE M R, MITCHELL S, SAWYER A, et al.. Continuous glucose monitoring: the future of diabetes management [J]. Diabetes Spectrum, 2008,21(2):112-119.[7] BECK R W, HIRSCH I B, LAFFEL L, et al.. The effect of continuous glucose monitoring in well-controlled type 1 diabetes [J]. Diabetes Care, 2009,32(8):1378-1383.[8] TAMBORLANE W V, BECK R W, BODE B W, et al.. Continuous glucose monitoring and intensive treatment of type 1 diabetes [J]. The New England Journal of Medicine, 2008,359(14):1464-1476.[9] MITRAGOTRI S. Synergistic effect of enhancers for transdermal drug delivery [J]. Pharmaceutical Research, 2000,17(11):1354-1359.[10] KOST J, MITRAGOTRI S, GABBAY R A, et al.. Transdermal monitoring of glucose and other analytes using ultrasound [J]. Nature Medicine, 2000,6:347-350.

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Related Institution

State Key Laboratory of Precision Measuring Technology and Instruments, School of Precision Instrument and Optoelectronics Engineering, Tianjin University

天津大学精密测试技术及仪器国家重点实验室

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