Automatic identification of vulnerable plaques based on intravascular ultrasound images

ZHANG Qi; WANG Yuan-yuan; MA Jian-ying; QIAN Ju-ying; SHI Jun; YAN Zhuang-zhi

doi:10.3788/OPE.20111910.2507

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Automatic identification of vulnerable plaques based on intravascular ultrasound images

Article | 更新时间：2020-08-12

- Automatic identification of vulnerable plaques based on intravascular ultrasound images
- Optics and Precision Engineering Vol. 19, Issue 10, Pages: 2507-2519(2011)
- 作者机构：
  
  1. 复旦大学电子工程系上海,200433
  2. 上海大学通信与信息工程学院上海,200072
  3. 复旦大学附属中山医院心内科上海,200032
- 作者简介：
- 基金信息：
- DOI：10.3788/OPE.20111910.2507
  CLC： TB559;TP391.4
- Received：13 December 2010，
  
  Revised：17 February 2011，
  
  Published Online：27 October 2011，
  
  Published：25 October 2011
- 稿件说明：
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张麒, 汪源源, 马剑英, 钱菊英, 施俊, 严壮志. 基于血管内超声图像自动识别易损斑块[J]. 光学精密工程, 2011,19(10): 2507-2519

ZHANG Qi, WANG Yuan-yuan, MA Jian-ying, QIAN Ju-ying, SHI Jun, YAN Zhuang-zhi . Automatic identification of vulnerable plaques based on intravascular ultrasound images[J]. Editorial Office of Optics and Precision Engineering, 2011,19(10): 2507-2519
张麒, 汪源源, 马剑英, 钱菊英, 施俊, 严壮志. 基于血管内超声图像自动识别易损斑块[J]. 光学精密工程, 2011,19(10): 2507-2519 DOI： 10.3788/OPE.20111910.2507.

ZHANG Qi, WANG Yuan-yuan, MA Jian-ying, QIAN Ju-ying, SHI Jun, YAN Zhuang-zhi . Automatic identification of vulnerable plaques based on intravascular ultrasound images[J]. Editorial Office of Optics and Precision Engineering, 2011,19(10): 2507-2519 DOI： 10.3788/OPE.20111910.2507.

摘要

为克服手工判别动脉粥样硬化易损斑块耗时耗力、主观性强、重复性差等缺点

研究了基于血管内超声自动识别易损斑块的方法。首先将Contourlet变换与Snake模型相结合进行斑块的图像分割

提取内腔轮廓与外弹力膜。接着实现经典形态特征的计算机自动提取

并提取纹理、弹性两类新特征以量化斑块属性

其中纹理特征包括一阶统计量和灰度共生矩阵特征

弹性特征的提取则基于非刚性图像配准。最后设计Fisher线性判别、支撑向量机、广义相关学习矢量量化3种分类器进行分类判决。对124例斑块(36例易损

88例非易损)的实验结果表明:20个形态特征、24个纹理特征和6个弹性特征在两类斑块间存在显著性差异(

0.05);采用三类特征由支撑向量机进行分类时效果最好

在测试集上敏感性、特异性、准确率和约登指数分别达到91.7%、97.7%、96.7%和89.4%

表明利用血管内超声图像中斑块的三类特征能自动、准确地识别易损斑块。

Abstract

In order to overcome drawbacks in manual identification of vulnerable atherosclerotic plaques

a method for automatic identification of vulnerable plaques is proposed based on computerized analysis of intravascular ultrasound images. First

the Contourlet transform is combined with the Snake model to segment images and detect lumen borders and external elastic membranes. Two categories of new features representing texture and elasticity of plaques are then automatically extracted to quantitate the features of plaques. The texture features consist of first-order statistics and features from the gray-level coocurrence matrix

and the elastic features are extracted from strain tensors estimated by nonrigid image registration. Finally

three types of features are used to design classifiers including Fisher linear discrimination

support vector machines

and generalized relevance learning vector quantization. The experimental results on 124 plaques

consisting of 36 vulnerable and 88 nonvulnerable ones

reveals that 20 morphological features

24 texture features and 6 elastic features has significant difference (

0.05) between the two types of plaques.The Support Vector Machine(SVM) outperformes the other two classifiers with the sensitivity

specificity

correct rate

and Youdens index of 91.7%

97.7%

96.7%

and 89.4%

respectively. Therefore

the proposed method can automatically and accurately identify vulnerable plaques.

关键词

Keywords

references

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