Quantitative spectral domain optical coherence tomography and its application to quantitative analysis of biological tissues

ZHANG Qin-qin; WU Xiao-jing; ZHU Si-wei; GAO Zhi; YUAN Xiao-cong

doi:10.3788/OPE.20122006.1188

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Quantitative spectral domain optical coherence tomography and its application to quantitative analysis of biological tissues

更新时间：2020-08-12

- Quantitative spectral domain optical coherence tomography and its application to quantitative analysis of biological tissues
- Optics and Precision Engineering Vol. 20, Issue 6, Pages: 1188-1193(2012)
- 作者机构：
  
  1. 南开大学现代光学研究所光学信息技术科学教育部重点实验室天津,300071
  2. 南开大学人民医院分子医学与纳米光学实验室天津,300121
  3. 克莱姆森大学生物工程系,南罗来纳州克莱姆森,29634
- 作者简介：
- 基金信息：
- DOI：10.3788/OPE.20122006.1188
  CLC： Q-331;R814.42
- Received：27 December 2011，
  
  Revised：01 March 2012，
  
  Published Online：10 June 2012，
  
  Published：10 June 2012
- 稿件说明：
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张芹芹, 吴晓静, 朱思伟, 高志, 袁小聪. 谱域光学相干层析成像量化技术及其在生物组织定量分析中的应用[J]. 光学精密工程, 2012,20(6): 1188-1193

ZHANG Qin-qin, WU Xiao-jing, ZHU Si-wei, GAO Zhi, YUAN Xiao-cong. Quantitative spectral domain optical coherence tomography and its application to quantitative analysis of biological tissues[J]. Editorial Office of Optics and Precision Engineering, 2012,20(6): 1188-1193
张芹芹, 吴晓静, 朱思伟, 高志, 袁小聪. 谱域光学相干层析成像量化技术及其在生物组织定量分析中的应用[J]. 光学精密工程, 2012,20(6): 1188-1193 DOI： 10.3788/OPE.20122006.1188.

ZHANG Qin-qin, WU Xiao-jing, ZHU Si-wei, GAO Zhi, YUAN Xiao-cong. Quantitative spectral domain optical coherence tomography and its application to quantitative analysis of biological tissues[J]. Editorial Office of Optics and Precision Engineering, 2012,20(6): 1188-1193 DOI： 10.3788/OPE.20122006.1188.

摘要

研究了谱域光学相干层析(SDOCT)成像系统的量化技术

通过量化OCT图像来获得生物组织内部的信息特征对组织光学散射特性进行定量分析。给出并讨论了单次散射模型

具有轴向点散射函数(PSF)的单次散射模型和多次散射模型

利用平均A-scan算法和非线性最小二乘法曲线拟合

研究不同浓度Intralipid

溶液的散射特性。实验显示

Intralipid

溶液的散射系数与浓度在1%~10%间基本呈线性关系

验证了具有PSF的单次散射模型比较适用于本文的谱域光学相干层析成像系统。利用该模型对小鼠的新鲜肝脏进行量化研究

得到小鼠新鲜肝脏在波长

为1550 nm时的散射系数为8.9 mm

-1

。本文的研究为该项技术今后在临床医学上对各种疾病的诊断和治疗奠定了基础。

Abstract

The quantitative analysis of spectral domain optical coherence tomography was researched to acquiring interior information of biological tissues.The single-scattering model

confocal single-scattering model and multiple-scattering model were presented and discussed. An average A-scan algorithm and a nonlinear curve-fitting method were employed to explore the scattering features of Intralipid

. Experiments show that the relation of scattering coefficients and concentrations is linear in concentrations from 1% to 10% of Intralipid

.Fourthermore

it confirm that the confocal single-scattering model is suitable to our spectral domain optical coherence tomography. In addition

the confocal model was used to study fresh rat liver with a scattering coefficient

of 8.9 mm

-1

at 1 550 nm. Obtained results demonstrate that the quantitative spectral domain optical coherence tomography can be used for clinical diagnosis of diseases in a great potential.

关键词

Keywords

references

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VAN LEEUWEN T G,FABER D J,AALDERS M C, et al.. Measurement of the axial point spread function in scattering media using single-mode fiber-based optical coherence tomography[J]. Quantum Electron., 2003, 9:227-233.

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