Scanning surface plasmon resonance biosensor for array sample detection

QI Pan; LI Ying; FENG Ming-chuang; ZHONG Jin-gang

doi:10.3788/OPE.20122011.2365

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Scanning surface plasmon resonance biosensor for array sample detection

Article | 更新时间：2020-08-12

- Scanning surface plasmon resonance biosensor for array sample detection
- Optics and Precision Engineering Vol. 20, Issue 11, Pages: 2365-2372(2012)
- 作者机构：
  
  1. 暨南大学光电工程系, 广东广州 510632
  2. 广东交通职业技术学院电子工程系,广东广州,510650
  3. 暨南大学光电信息与传感技术广东普通高校重点实验室, 广东广州 510632
- 作者简介：
- 基金信息：
- DOI：10.3788/OPE.20122011.2365
  CLC： TP212.3
- Received：25 May 2012，
  
  Revised：03 July 2012，
  
  Published：10 November 2012
- 稿件说明：
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齐攀, 李莹, 冯明创, 钟金钢. 用于阵列样品检测的扫描式表面等离子体共振生物传感器[J]. 光学精密工程, 2012,20(11): 2365-2372

QI Pan, LI Ying, FENG Ming-chuang, ZHONG Jin-gang. Scanning surface plasmon resonance biosensor for array sample detection[J]. Editorial Office of Optics and Precision Engineering, 2012,20(11): 2365-2372
齐攀, 李莹, 冯明创, 钟金钢. 用于阵列样品检测的扫描式表面等离子体共振生物传感器[J]. 光学精密工程, 2012,20(11): 2365-2372 DOI： 10.3788/OPE.20122011.2365.

QI Pan, LI Ying, FENG Ming-chuang, ZHONG Jin-gang. Scanning surface plasmon resonance biosensor for array sample detection[J]. Editorial Office of Optics and Precision Engineering, 2012,20(11): 2365-2372 DOI： 10.3788/OPE.20122011.2365.

摘要

针对阵列样品的定量检测

构建了一种用于阵列样品检测的扫描式表面等离子体共振生物传感器。首先

基于平面棱镜耦合下的最佳旋转轴位置和双棱镜探测光路搭建了阵列扫描式表面等离子体共振生物传感器。然后

计算了可探测阵列样品的点密度。最后

以蒸馏水和浓度分别为5

35 mg/mL的葡萄糖溶液作为待测阵列样品进行了多样品点的表面等离子体共振实验。实验测得阵列样品的共振角分别为73.745

73.919

74.052

74.185

74.306

74.408

74.549

74.660

显示葡萄糖溶液浓度与共振角线性关系良好

证明了该方法和装置的可行性。该装置对提高阵列样品点密度

实现高精度定量检测具有重要意义。

Abstract

An scanning surface plasmon resonance biosensor was constructed to quantitatively detect array samples. First

based on the optimal rotation position in plane prism-coupling mode and a double-prism detection optical path

the scanning surface plasmon resonance biosensor for array samples was constructed. Then

the sample density of array samples was calculated. Finally

by taking the distilled water and glucose solution with different concentrations in 5

30 and 35 mg/mL as array samples to be measured

the multi-sample spots were detected by surface plasmon resonance method. Experimental results show that the resonance angles of array samples are 73.745

73.919

74.052

74.185

74.306

74.408

74.549 and 74.660

respectively

and the solution concentrations and their resonance angles show a good linear relation

which proves that the proposed method and device are feasibility. The device is significant for increasing the sample density of array samples and realizing the high precision detection.

关键词

Keywords

references

SCHASFOORT R B M, TUDOS A J. Handbook of Surface Plasmon Resonance[M]. Royal Society of Chemistry, 2008.[2] KABASHIN A V, NIKITIN P I. Surface plasmon resonance in-terferometer for bio-and chemical-sensors [J]. Optics Communications,1998,150(1-6):5-8.[3] MULLETT W M, LAI E P C, YEUNG J M. Sur-face plasmon resonance-based immunoassays [J]. Meth-ods,2000,22(1):77-91.[4] MYSZKA D G, RICH R L. Implementing surface plasmon resonance biosensors in drug discovery [J]. Pharmaceutical Science & Technology Today, 2003, 3(9): 310-317.[5] HOMOLA J, LU H B, YEE S S. Dual-channel surface plasmon resonance sensor with spectral discrimination of sensing channels using dielectric overlayer [J]. Electronics Letters, 1999, 35(13):1105-1106.[6] NELSON B P, GRIMSRUD T E, LILES M R, et al.. Surface plasmon resonance imaging measurements of DNA and RNA hybridization adsorption onto DNA microarrays [J]. Analytical Chemistry, 2001, 73(1): 1-7.[7] YUK J S, KIM H S, JUNG J W, et al.. Analysis of protein interactions on protein arrays by a novel spectral surface plasmon resonance imaging [J]. Biosensors and Bioelectronics, 2006, 21: 1521-1528.[8] QI P, LI Y, ZHONG J G. Optimized angle scanning method for array sample detection in surface plasmon resonance biosensor [J]. Applied Optics, 2012, 51(9):1245-1250.[9] YEH LY. Real-time measurement of glucose concentration and average refractive index using a laser interferometer [J]. Opt. Lasers in Eng., 2008,46(9): 666-670.[10] 刘畅, 邹正峰, 陈淑芬,等. 基于光盘光栅的表面等离子体共振传感器[J]. 中国激光, 2012, 39(3): 0314001-1-0314001-4. LIU CH, ZOU ZH F, CHEN SH F, et al.. Surface plasmon resonance sensor based on compact disk grating [J]. Chinese Journal of Lasers, 2012, 39(3): 0314001-1-0314001-4. (in Chinese)

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