Optofluidic waveguides and their applications to biological sensors

LI Yong-Qian; SU Lei; MAN Li; SHOU Chen; YE Fang; XU Zheng

doi:10.3788/OPE.20132104.0987

您当前的位置：

首页 >

文章列表页 >

Optofluidic waveguides and their applications to biological sensors

更新时间：2020-08-12

- Optofluidic waveguides and their applications to biological sensors
- Optics and Precision Engineering Vol. 21, Issue 4, Pages: 987-999(2013)
- 作者机构：
  
  1. 西北工业大学空天微纳系统教育部重点实验室
  2. 大连理工大学辽宁省微纳米技术及系统重点实验室
- 作者简介：
- 基金信息：
- DOI：10.3788/OPE.20132104.0987
  CLC： TN252;TP212.3
- Received：02 November 2012，
  
  Revised：25 December 2012，
  
  Published Online：20 April 2013，
  
  Published：15 April 2013
- 稿件说明：
移动端阅览
黎永前苏磊满力寿宸叶芳徐征. 微纳流体光波导技术及其在生物传感器中的应用[J]. 光学精密工程, 2013,21(4): 987-999

LI Yong-Qian SU Lei MAN Li SHOU Chen YE Fang XU Zheng. Optofluidic waveguides and their applications to biological sensors[J]. Editorial Office of Optics and Precision Engineering, 2013,21(4): 987-999
黎永前苏磊满力寿宸叶芳徐征. 微纳流体光波导技术及其在生物传感器中的应用[J]. 光学精密工程, 2013,21(4): 987-999 DOI： 10.3788/OPE.20132104.0987.

LI Yong-Qian SU Lei MAN Li SHOU Chen YE Fang XU Zheng. Optofluidic waveguides and their applications to biological sensors[J]. Editorial Office of Optics and Precision Engineering, 2013,21(4): 987-999 DOI： 10.3788/OPE.20132104.0987.

摘要

微纳流体光波导融合了微观流体与微光学特征，能够在相同物理空间实现流体介质和微光学信息功能及结构的集成，是生物化学分析及生物传感器的关键器件。本文综述了微纳流体光波导研究现状及其在生物传感器和生物化学分析中的应用实例。论述了实现微纳流体光波导的全反射机理、多层干涉效应，抗谐振反射机理，以及基于上述机理实现的各种流体波导形式。重点分析了基于微纳流体层流效应的全流体波导，基于多层干涉效应的Bragg光波导、空心光子晶体波导、狭缝光流体波导、抗谐振反射光波导等多种波导的特点。指出狭缝光流体波导和抗谐振反射光波导具有更好的设计灵活性，且检测灵敏度高、可靠性好、易于集成制造，可望在生物传感器及微纳流体光学系统中得到更广泛的应用。

Abstract

Optofluidic waveguides can integrate the functions and structures of fluid media and micro-optical information in the same physical space because of the fusion of the microfluidic/nanofluidics and the micro-optics. They have been the key devices for biochemical analysis and biosensors. This paper overviews the research status of the optofluidic waveguides and their applications to biochemical analysis and biosensors. It describes the basic principles to implement different fluid waveguides

such as total reflection principles

multi-layer interference effect and antiresonant reflecting mechanism

and gives a lots of waveguide forms according to the principles mentioned above. It focuses on the analysis of the characteristics of total fluid waveguides based on micro/nano fluidic layers

Bragg waveguides based on interference effect

hollow core photonic crystal waveguides

slit fluid waveguides and antiresonant reflecting waveguides. Finally

it points out that the latter two waveguides can be designed in flexibility and is characterized by higher sensibility

good reliability and easy to be fabricated

so that they are expected to widely used in biosensors and microfluidic/nanofluidic systems.

关键词

Keywords

references

DEMETRI PSALTIS, QUAKE S R. Insight review: developing optofluidic technology through the fusion of microfluidics and optics [J]. Nature,2006, 442:381-384.[2]MONAT C, DOMACHUK P, EGGLETON B J. Integrated optofluidics: a new river of light [J].Nature Photonics,2007, 1: 106 -114.[3]KORFMACHER W A.Foundation review: Principles and applications of LC-MS in new drug discovery [J].Drug Discov Today, 2005,10:1357-1367.[4]RAMANATHAN K,DANIELSSON B.Principles and applications of thermal biosensors[J].Biosensors and Bioelectronics,2001,16:417-423.[5]POHANKA M,SKLDAL P.Electrochemical biosensors-principles and applications[J].J. Appl. Biomed,2008, 6: 57-64.[6]KUSWANDI B, NURIMAN, HUSKENS J,et al.. Optical sensing systems for microfluidic devices: A review[J].Analytica chimica acta,2007, 601:141-155.[7]ERICKSON D, MANDAL S, YANG A H J, et al.. Nanobiosensors: optofluidic, electrical and mechanical approaches to biomolecular detection at the nanoscale [J].Microfluid Nanofluidics,2008, 4:33-52.[8]YOLE DEVELOPMENT.Emerging markets for microfluidic applications in life sciences and in-vitro diagnostics [R]. Micromachine Summit, 2010.[9]PANG L, CHEN H M, FREEMAN L M, et al..Optofluidic devices and applications in photonics, sensing and imaging [J].Lab Chip,2012,12:3543-3551.[10]WHITESIDES G M, The origins and the future of microfluidics [J].Nature,2006,442:368-373.[11]SONG W, PSALTIS D.Pneumatically tunable optofluidic 2X2 switch for reconfigurable optical circuit [J].Lab Chip,2011,11:2397-2402.[12]YANG A H J, ERICKSON D.Optofluidic ring resonator switch for optical particle transport[J].Lab Chip ,2010,10: 769-774.[13]HENG X, ERICKSON D, BAUGH LR, et al..Optofluidic microscopy--a method for implementing a high resolution optical microscope on a chip [J]. Lab on a Chip,2006, 6:1274-1276.[14]CAMPBELL K, GROISMAN A, LEVY U, et al..A microfluidic 2X2 optical switch [J].App. Phys. LET,2004,85: 6119-6121.[15]LI Z, ZHANG Z, SCHERER A, et al.. Mechanically tunable optofluidic distributed feedback dye laser [J].Opt. Express,2006, 14: 10494-10499.[16]YU J Q , YANG Y, LIU A Q, et al..Microfluidic droplet grating for reconfigurable optical diffraction [J].Opt. Lett,2010, 35: 1890-1892.[17]ERICKSON D.Special issue on Optofluidics [J].Microfluidics and Nanofluidics ,2008,4:1-2.[18]SCHMIDT H, HAWKINS A R.Optofluidic wave-guides: I. Concepts and implementations[J].Microfluid Nanofluid,2008,4:3-16.[19]DATTA A, EOM I, DHAR A, et al..Microfabrication and characterization of teflon AF-coated liquid core waveguide channels in silicon[J].IEEE,Sens J,2003,3:788-795.[20]WU C, GONG G. Fabrication of PDMS-based nitrite sensors using teflon AF coating microchannels [J].IEEE,Sensors Journal,2008, 8:465-469.[21]WALHEIM S, SCHAFFER E, MLYNEK, J et al..Nanophase-separated polymer films as high- performance antireflection coatings[J].Science,1999, 283:520-522.[22]KIM H C, WILDS J B, KRELLER C R, et al..Fabrication of multilayered nanoporous poly(methyl silsesquioxane) [J].Advanced Materials,2002, 14:1637-1639.[23]GOPALAKRISHNAN N, SAGAR K S, CHRISTIANSEN M B, et al..UV patterned nanoporous solid-liquid core waveguides [J]. Opt Express,2010,18:12903-12908.[24]RISK W P, KIM H C, MILLER R D, et al..Optical waveguides with an aqueous core and a low-index nanoporous cladding[J].Opt. Expression,2004, 12:6446-6455.[25]KORAMPALLY V, MUKHERJEE S, HOSSAIN M, et al.. Development of a miniaturized liquid core waveguide system with nanoporous dielectric cladding-a potential biosensing platform [J].Sensors Journal, IEEE,2009,9:1711-1718.[26]JUNEMO K.Liquid flow in microchannels: experimental observations and computational analyses of microfluidics effects[J].J. Micromech. Microeng.,2003, 13:568.[27]WEIBEL D B, WHITESIDES A.Applications of microfluidics in chemical biology[J].Curr. Opin. Chem. Biol.,2006,10:584-591.[28]BEEBE D J, GLENNYS A. MENSING, et al..Physics and applications of microfluidics in biology [J].Annu. Rev. Biomed. Eng.,2002, 4:261-286.[29]YANG Y, LIU A Q, CHIN L K, et al..Optofluidic waveguide as a transformation optics device for lightwave bending and manipulation[J].Nature Communication,2012, 3:651.[30]WOLFE D B, CONROY R S, GARSTECKI P, et al..Dynamic control of liquid-core/liquid-cladding optical waveguides[J].P Natl Acad Sci Usa ,2004,101:12434-12438.[31]WOLFE D B, VEZENOV D V, MAYERS B T, et al..Diffusion-controlled optical elements for optofluidics [J].Appl Phys Lett,2005,87:181105.[32]VEZENOV D B, MAYERS B T, WOLFE D B, et al.. Integrated fluorescent light source for optofluidic applications[J].Appl Phys Lett,2005, 86:41104.[33]KANG S L, SANG Y Y, KYUNG H L, et al..Optofluidic particle manipulation in a liquid-core/liquid-cladding waveguide[J].Optics Express,2012, 20:17349.[34]LI X C, WU J, LIU A Q, et al..A liquid waveguide based evanescent wave sensor integrated onto a microfluidic chip[J].Appl Phys Lett ,2008,93:193901.[35]LEE K S, YOON S Y, LEE K H, et al.. Radiation forces on a microsphere in an arbitrary refractive index profile [J].J. Opt. Soc. Am. B,2012, 29:407-414.[36]TANG S K Y.Optical waveguiding using thermal gra-dients across homogeneous liquids [J].Appl. Phys. Lett.,2006, 88:61112.[37]ROSENAUER M, VELLEKOOP M J.A versatile liquid-core/liquid-twin-cladding waveguide micro flow cell fabricated by rapid prototyping [J].Appl. Phys. Lett.,2009, 95:163702-163703.[38]TAKIGUCHI H, ODAKE T, OZAKI M, et al..Liquid/Liquid optical waveguides using sheath flow as a new tool for liquid/liquid interfacial measurements [J].Appl. Spectrosc.,2003,57:1039-1041.[39]LEE K S, KIM S B, LEE K H, et al..Three-dimensional microfluidic liquid-core/liquid-cladding waveguide[J].Appl Phys Lett ,2010,97:21109.[40]ROWLAND K J, AFSHAR S, STOLYAROV A, et al..Bragg waveguides with low-index liquid cores[J].Opt Express ,2012,20:48-62.[41]FINK Y, RIPIN D J, FAN S, et al..Guiding optical light in air using an all-dielectric structure [J].J Lightwave Technol.,1999,17:2039-2041.[42]ROWLAND K J, AFSHAR S V, STOLYAROV A, et al..Spectral properties of liquid-core Bragg fibers [C]. Conference on Lasers and Electro-Optics/International Quantum Electronics Conference,Optical Society of America, 2009.[43]PARKER R M, GATES J C, SMITH P, et al..Optofluidic Bragg grating sensor for monolayer detection[C]. International Conference on Lasers and Electro-Optics, Baltimore, USA , 2009.[44]QU H, SKOROBOGATIY M.Liquid-core low-refractive-index-contrast Bragg fiber sensor [J].Appl. Phys. Lett.,2011,98: 201113-201114.[45]MASELLI V, GRENIER J R, HO S, et al..Femtosecond laser written optofluidic sensor: Bragg grating waveguide evanescent probing of microfluidic channel [J]. Opt Express,2009, 17:11719-11729.[46]GARBOS M K, EUSER T G, RUSSELL P S J.Optofluidic immobility of particles trapped in liquid-filled hollow-core photonic crystal fiber [J].Opt Express,2011, 19: 19643-19652.[47]YAN H, GU C, YANG C, et al..Hollow core photonic crystal fiber surface-enhanced Raman probe [J].Appl. Phys. Lett.,2006, 89: 204101.[48]RINDORF L, JENSEN J B, DUFVA M, et al..Photonic crystal fiber long-period gratings for biochemical sensing[J].Opt. Express,2006, 14:8224-8231.[49]SMOLKA S, BARTH M.Selectively coated photonic crystal fiber for highly sensitive fluorescence detection [J].Appl. Phys. Lett.,2007,90:111101.[50]MANDAL S E D. Optofluidic transport in liquid core waveguiding structures [J].Appl. Phys. Lett.,2007, 90:184103.[51]SMOLKA S, BARTH M, BENSON O.Highly efficient fluorescence sensing with hollow core photonic crystal fibers [J].Opt Express,2007, 15:12783-12791.[52]ERICKSON D, ROCKWOOD T, EMERY T, et al..Nanofluidic tuning of photonic crystal circuits[J].Opt. Lett,2006, 31:59-61.[53]BENABID F, ROBERTS P J, COUNY F, et al..Light and gas confinement in hollow-core photonic crystal fibre based photonic microcells [J].J. Eur. Opt. Soc.,2009, 4:1-9.[54]WANG Y Y, COUNY F, LIGHT P S, et al..Compact and portable multiline UV and visible Raman lasers in hydrogen-filled HC-PCF[J]. Opt. Lett,2010, 35:1127-1129.[55]UNTERKOFLER S, MCQUITTY R J,EUSER T G, et al..Optofluidic hollow-core photonic crystal fiber coupled to mass spectrometry for rapid photochemical reaction analysis [C].Lasers and Electro-Optics, 2012.[56]CHEN J S Y, EUSER T G, FARRER N J, et al..Photochemistry in photonic crystal fiber nanoreactors[J].Chemistry-A European Journal,2010, 16:5607-5612.[57]UNTERKOFLER S, MCQUITTY R J, EUSER T G, et al..Microfluidic integration of photonic crystal fibers for online photochemical reaction analysis [J]. Opt. Lett,2012, 37:1952-1954.[58]ALMEIDA V R, XU Q, BARRIOS C A, et al..Guiding and confining light in void nanostructures[J].Opt. Lett.,2004,29: 1209-1211.[59]XU Q, ALMEIDA V R, PANEPUCCI R R, et al..Experimental demonstration of guiding and confining light in nanometer-size low-refractive-index material [J]. Opt. Lett ,2004,29:1626-1628.[60]BARRIOS C A.Optical slot-waveguide based biochemical sensors [J]. Sensors,2009,9:4751-4765.[61]CARLBORG C F, GYLFASON K B, KAZMIERCZAK A, et al..A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips [J].Lab Chip,2010, 10:281-290.[62]BARRIOS C A, GYLFASON K B, SCHEZ B, et al..Slot-waveguide biochemical sensor[J].Opt. Lett,2007,32:3080-3082.[63]DELL'OLIO F, PASSARO V M.Optical sensing by optimized silicon slot waveguides [J].Opt. Express,2007,15: 4977-4993.[64]TESTA G, BERNINI R.Slot and layer-slot wav-eguide in the visible spectrum [J].Journal of Lightwave Technology,2011, 29:2979.[65]DUGUAY M A, KOKUBUN Y, KOCH T, et al..Antiresonant reflecting optical waveguides in SiO2–Si multilayer structures [J].Appl. Phys. Lett.,1986, 49:13-15 .[66]MAWST L J, BOTEZ D, ZMUDZINSKI C, et al..Design optimization of ARROW-type diode lasers [J].IEEE Phot. Technol. Lett.,1992:1204-1206.[67]YIN D, SCHMIDT H, BARBER J, et al..Integrated ARROW waveguides with hollow cores [J].Opt Express,2004, 12: 2710-2715.[68]ARCHAMBAULT J L, BLACK R J, LACROIX S, et al..Loss calculations for antiresonant waveguides [J].J. Lightwave Technol.1993, 11:416-423.[69]DELONGE T F H.Integrated optical detection cell based on Bragg reflecting waveguides [J]. J. Chromat A.,1995, 716:135-139.[70]TESTA G, YUJIAN H, ZENI L, et al..Liquid core ARROW waveguides by atomic layer deposition[J].Photonics Technology Letters, 2010,IEEE 22:616-618.[71]SCHMIDT H, YIN D, BARBER J P, et al..Hollow-core waveguides and 2D waveguide arrays for integrated optics of gases and liquids [J].IEEE J Sel Top Quantum Electron,2005,11:519-527.[72]YIN D, SCHMIDT H, BARBER J P, et al..Optical characterization of arch-shaped ARROW waveguides with liquid cores[J].Opt Express,2005,13:10564-10570.[73]P B J, J L E, A G Z , et al.. Integrated hollow waveguides with arch-shaped cores[J].Photonics Technology Letters,2006, IEEE 18:28-30.[74]TESTA G, YUJIAN H, ZENI L, et al..Hybrid silicon-PDMS optofluidic ARROW waveguide [J].Photonics Technology Letters,2012, IEEE 24:1307-1309.[75]LUNT E J, BIN W, KEELEY J M, et al..Hollow ARROW waveguides on self-aligned pedestals for improved geometry and transmission [J].Photonics Technology Letters,2010, IEEE 22:1147-1149.[76]BERNINI R, CAMPOPIANO S, ZENI L, et al..ARROW optical waveguides based sensors[J].Sens. Actuators,2004,B 100:143-146 .[77]YIN D, BARBER J P, HAWKINS A R, et al..Integrated optical waveguides with liquid cores[J].Appl. Phys. Lett.,2004, 85:3477-3479.[78]CAMPOPIANO S, BERNINI R, ZENI L, et al..Microfluidic sensor based on integrated optical hollow waveguides[J].Opt. Lett.,2004, 29:1894-1896.[79]BERNINI R, DENUCCIO E, MINARDO A, et al..Integrated silicon optical sensors based on hollow core waveguide [J]. Proc SPIE ,2007,6477:647714.[80]PRIETO F,SEPULVEDA B,CALLE A,et al.. Integrated Mach-Zehnder interferometer based on ARROW structures for biosensor applications.Sensors and Actuators B: Chemical. 2003,92:151-158.[81]YIN D, BARBER J P, DEAMER D W, et al..Single-molecule detection sensitivity using planar integrated optics on a chip[J].Opt. Lett.,2006, 31:2136-2138.[82]TESTA G, HUANG Y, SARRO P M, et al..High-visibility optofluidic MachZehnder interferometer [J].Opt. Lett., 2010,35: 1584-1586.[83]TESTA G, HUANG Y, ZENI L, et al..Optofluidics: waveguides and devices[J].Proc. SPIE, Integrated Optics: Devices, Materials, and Technologies,2012,XVI 8264:826415.[84]BERNINI R, TESTA G, ZENI L, et al..Integrated optofluidic Mach-Zehnder interferometer based on liquid core waveguides [J]. Appl. Phys. Lett.,2008,93:11103-11106.[85]LUNT E J, MEASOR P, PHILLIPS B S, et al..Improving solid to hollow core transmission for integrated ARROW waveguides[J]. Opt Express,2008, 16:20981-20986.[86]YIN D, BARBER J, HAWKINS A, et al..Waveguide loss optimization in hollow-core ARROW waveguides [J].Opt. Express,2005, 13:9331-9336.[87]FURLANI E P, BISWAS R, CARTWRIGHT A N, et al..Antiresonant guiding optofluidic biosensor [J].Opt. Commun.,2011, 284:4094-4098.[88]OZCELIK D, PHILLIPS B S, PARKS J W, et al..Dual-core optofluidic chip for independent particle detection and tunable spectral filtering [J].Lab. Chip., 2012:3728-3733.[89]LI Z, PSALTIS D.Optofluidic dye lasers [J].Microfluid Nanofluid ,2008,4:145-158.

Views

104

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

AI问答

Address：No.3888 Dong Nanhu Road, Changchun, Jilin, China Postal code：130033
Tel：0431-86176855 Email：gxjmgc@ciomp.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 吉ICP备11002662号-17 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰