Low-coherence measuring glucose in solution based on inverse Monte Carlo method

LIN Lin; ZHANG Mei

doi:10.3788/OPE.20132109.2231

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Low-coherence measuring glucose in solution based on inverse Monte Carlo method

更新时间：2020-08-12

- Low-coherence measuring glucose in solution based on inverse Monte Carlo method
- Optics and Precision Engineering Vol. 21, Issue 9, Pages: 2231-2237(2013)
- 作者机构：
  
  1. ．广东医学院信息工程学院，广东东莞 523808
  2. ．东莞理工学院电子工程学院，广东东莞 523808
- 作者简介：
- 基金信息：
- DOI：10.3788/OPE.20132109.2231
  CLC： R318.51
- Received：10 April 2013，
  
  Revised：28 May 2013，
  
  Published Online：30 September 2013，
  
  Published：15 September 2013
- 稿件说明：
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林林张梅. 基于逆向蒙特卡洛的溶液葡萄糖浓度低相干测量[J]. 光学精密工程, 2013,21(9): 2231-2237

LIN Lin ZHANG Mei. Low-coherence measuring glucose in solution based on inverse Monte Carlo method[J]. Editorial Office of Optics and Precision Engineering, 2013,21(9): 2231-2237
林林张梅. 基于逆向蒙特卡洛的溶液葡萄糖浓度低相干测量[J]. 光学精密工程, 2013,21(9): 2231-2237 DOI： 10.3788/OPE.20132109.2231.

LIN Lin ZHANG Mei. Low-coherence measuring glucose in solution based on inverse Monte Carlo method[J]. Editorial Office of Optics and Precision Engineering, 2013,21(9): 2231-2237 DOI： 10.3788/OPE.20132109.2231.

摘要

为了更加准确的研究血糖对光学参数的影响，提出了基于蒙特卡洛逆运算的葡萄糖含量低相干干涉测量方法，并从光学参数的相关性角度进行了理论分析。通过正向蒙特卡洛数值模拟说明了从干涉曲线中同时求解散射和吸收系数的条件和可行性。以脂肪乳悬混溶液Intralipid作为实验对象，研究了糖浓度变化对深度相关干涉信号的影响。利用低相干干涉测量系统配合逆向蒙特卡洛计算提取了散射和吸收系数，进而通过散射和吸收系数的变化量间接获得了溶液葡萄糖含量。实验结果与双积分球测量结果进行了比较验证，测量存在可修正的系统误差。在加入修正值后，测量的散射和吸收系数的最大相对误差分别为2.52%和3.11%。研究结果表明了葡萄糖含量与散射系数和干涉曲线存在高度相关性，在非前向散射条件下，可以同时测量吸收和散射系数。经过校准后的测量结果可以满足实际要求。

Abstract

To evaluate effect of glucose on optical paramenters

a method of coherent measuring concertration of glucose in turbid suspension is presented based on inverse Monte Carlo algorithm. Corresspondens theories and techniques are elabrated in detail by Monte Carlo method. The feazibility of reconstruction of absorption and scattering coefficients simultaniously has been anslyzed with Monte Carlo method. Fat suspension

Intralipid

is taken as turbid sample which is popular biological phantom. There is obvious corelation between glucose and coherent signal. By invers Monte Carlo

the scattering and absorption coefficients of sample are extracted seperately. The scattering coefficient varies with concertration of glucose linearly. Results of low coherent measurement is proved by double integral sphere system with invariable systematic error. With proper correction

the maximum relative error are 2.52% and 3.11% for scattering and absorption coefficients respectively. Strong correlation between glucose and interferomic line as well as scattering coefficient is shown in experimental results. The research and experiment have prooved the feasibility of the method.

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references

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