Drug quantitative dispensing based on axial vibration microfeeding technology

WANG Xiao-peng; CHEN Tian-ning; LI Xin-xin

doi:10.3788/OPE.20142206.1584

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Drug quantitative dispensing based on axial vibration microfeeding technology

更新时间：2020-08-13

- Drug quantitative dispensing based on axial vibration microfeeding technology
- Optics and Precision Engineering Vol. 22, Issue 6, Pages: 1584-1589(2014)
- 作者机构：
  
  西安交通大学机械工程学院机械结构强度与振动国家重点实验室,陕西西安,710049
- 作者简介：
- 基金信息：
- DOI：10.3788/OPE.20142206.1584
  CLC： TQ460.6
- Received：11 December 2013，
  
  Revised：03 February 2014，
  
  Published：25 June 2014
- 稿件说明：
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王小鹏, 陈天宁, 李欣欣. 基于轴向振动配粉技术的药物微量配粉[J]. 光学精密工程, 2014,22(6): 1584-1589

WANG Xiao-peng, CHEN Tian-ning, LI Xin-xin. Drug quantitative dispensing based on axial vibration microfeeding technology[J]. Editorial Office of Optics and Precision Engineering, 2014,22(6): 1584-1589
王小鹏, 陈天宁, 李欣欣. 基于轴向振动配粉技术的药物微量配粉[J]. 光学精密工程, 2014,22(6): 1584-1589 DOI： 10.3788/OPE.20142206.1584.

WANG Xiao-peng, CHEN Tian-ning, LI Xin-xin. Drug quantitative dispensing based on axial vibration microfeeding technology[J]. Editorial Office of Optics and Precision Engineering, 2014,22(6): 1584-1589 DOI： 10.3788/OPE.20142206.1584.

摘要

针对轴向振动配粉技术在植入式可降解缓释给药系统微量配粉中的应用，搭建了轴向振动配粉实验台。采用毛细玻璃漏斗和圆锥状塑料吸头作为配粉管，研究两者稳定流动的振动幅值区间，讨论了振动频率对稳定出粉起始幅值、振动幅值对出粉流量及出粉流量稳定性的影响。结果表明：采用圆锥状塑料吸头作为配粉管的配粉过程更稳定，并且具有良好的抗堵性能；振动频率越大，实现配粉需要的起始激振幅度越小；在固定激振频率下，出粉流量随振幅先增大后减小，且管体中粉体处于充分流动状态；在激振频率为50 Hz，150 Hz，振幅为200~300 μm和35~50 μm时，可以得到最大且不随振幅改变的稳定出粉流量。实验论证了轴向振动配粉技术可以实现微量粉体的稳定、精确配给。

Abstract

For application of the axial vibration micro feeding technology to the quantitative dispensing of an implant control releasing drug micro system

an experimental apparatus based on the axial vibration method was set up. By using a glass capillary hopper and a conical plastic-tip as the dispending tubes

the vibration amplitude between both dispending tubes was researched and the influences of quantitative dispensing control parameters on the starting vibration amplitude

powder flow rate and the powder flow stability were discussed. The results show that the conical plastic-tip is a better dispensing tube with stable dispensing and good resistance to plugging. The higher the frequency

the lower the starting vibration amplitude needed to achieve desired starting feeding. At a constant excitation frequency

the flowing powder in the tube increases with the flow rate first

and then decreases to a stable value

meanwhile being a full flow state. Under both conditions with the excitation frequencies of 50 Hz

150 Hz and the amplitude between 200-300 μm and 35-50 μm

the maximum and stable powder flow rate can be obtained. It concludes that the axial vibration micro feeding technology can achieve stable

accurate dispensing of the drug powder.

关键词

Keywords

references

WANG X P, CHEN T N, YANG Z X. Study on structural optimum design of implantable drug delivery micro-system [J].Simulation Modelling Practice and Theory,2007,15(1):47-56.

王小鹏,陈天宁,杨战孝,等. 植入式 PLGA 给药系统释药仿真模型研究[J]. 系统仿真学报,2007,19(12):2816-2822. WANG X P, CHEN T N, YANG ZH X, et al.. Modeling and simulation of drug release from implantable PLGA drug delivery system [J]. Journal of System Simulation, 2007,19(12):2816-2822. (in Chinese)

王小鹏,刘志华,陈天宁. 透明材料微小器件键合质量检测系统设计[J]. 光学精密工程,2013.21(1):69-76. WANG X P, LIU ZH H, CHEN T N. Design of bonding quality testing system of micro device made by transparent material[J]. Opt. Precision Eng., 2013.21(1):69-76. (in Chinese)

YANG S, EVANS J. Metering and dispensing of powder; the quest for new solid freeforming techniques [J]. Powder Technology, 2007, 178 (1): 56-72.

侯丽雅, 王振琪, 章维一,等. 金属微粉体脉冲输送的微特性实验[J]. 光学精密工程, 2011, 19 (5):1030-1038. HOU L Y,WANG ZH Q,ZHANG W Y, et al.. Experiments of micro characteristics of pulse-transfer for micro metallic powders [J]. Opt. Precision Eng., 2013.21(1):69-76. (in Chinese)

KUMAR AV, ZHANG H. Electro photographic powder deposition for freeform fabrication [J]. Solid Freeform Fabrication Proceedings, Austin, Texas, 1999: 647-653.

LU X, YANG S, EVANS J R. Microfeeding with different ultrasonic nozzle designs [J]. Ultrasonics, 2009, 49 (6): 514-521.

GENG X, HOU L Y, ZHANG W Y. Implementation of the powder dispensing of digitization [C]. IEEE, 2010: 1169-1175.

张贵林,郭浩,赵淳生. 超声波粉体输送装置输送能力的实验研究[J]. 压电与声光,2002,(6):489-491,505. ZHANG G L,GUO H,ZHAO CH SH. Experimental study on the feeding ability of ultrasonic powder-feeding device[J].Piezoelectric & Acoustooptics,2002,(6):489-491,505.(in Chinese)

YANG Y, LI X. Experimental and analytical study of ultrasonic micro powder feeding [J]. Journal of Physics D: Applied Physics, 2003, 36 (11):1349.

盖国胜.粉体工程[M]. 北京:清华大学出版社,2009. GAI G S. Powder Engineering [M].Beijing: Qinghua University Press,2009.(in Chinese)

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