Femtosecond laser holograpic fabrication of hydrogel cell scaffold

Deng PAN; Jia-wen LI; Liang YANG; Yan-lei HU; Dong WU; Wen-hao HUANG; Jia-ru CHU

doi:10.3788/OPE.20172509.2277

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Femtosecond laser holograpic fabrication of hydrogel cell scaffold

Modern Applied Optics | 更新时间：2020-08-13

- Femtosecond laser holograpic fabrication of hydrogel cell scaffold
- Optics and Precision Engineering Vol. 25, Issue 9, Pages: 2277-2282(2017)
- 作者机构：
  
  中国科学技术大学精密机械与精密仪器系, 安徽合肥 230026
- 作者简介：
- 基金信息：
- DOI：10.3788/OPE.20172509.2277
  CLC： TN249;TH691.9
- Received：05 June 2017，
  
  Accepted：27 June 2017，
  
  Published：25 September 2017
- 稿件说明：
移动端阅览
Deng PAN, Jia-wen LI, Liang YANG, et al. Femtosecond laser holograpic fabrication of hydrogel cell scaffold[J]. Optics and precision engineering, 2017, 25(9): 2277-2282.
DOI：

Deng PAN, Jia-wen LI, Liang YANG, et al. Femtosecond laser holograpic fabrication of hydrogel cell scaffold[J]. Optics and precision engineering, 2017, 25(9): 2277-2282. DOI： 10.3788/OPE.20172509.2277.

摘要

为了实现以水凝胶为材料的细胞支架快速加工

将计算全息法引入传统的飞秒激光双光子加工中

并对全息图的生成方法和全息图对加工结构的影响进行了研究。首先

根据贝塞尔光波动方程和其透射函数生成贝塞尔光束全息图

分析两种参数对环形结构大小和质量的影响。然后利用生成的全息图加工得到壁厚800 nm、直径为8~15

m不等的水凝胶（PEGDA）圆管结构。最后

实现了基于圆管道的水凝胶细胞支架高效快速加工

支架中圆管道壁厚800 nm、直径为8

m。本文首次将飞秒激光全息加工技术应用于水凝胶三维支架加工

解决了飞秒激光单点加工效率的问题。该技术在生物医学中具有广阔的应用前景。

Abstract

In order to achieve rapid fabrication of hydrogel cell scaffolds

the computer-aided holographic method was employed into the traditional femtosecond laser two-photon processing. The generation of hologram as well as the influence of its parameters on the processed cylinder microstructure was studied. Firstly

Ring-shaped Bessel-beam holograms were generated according to the Bessel light wave equation and its transmission function

of which the parameters' effect on the size and quality of ring structure was analyzed. Then the generated holograms were used to process tubes with a thickness of 0.8

m and diameters from 8

m to 15

m in the polyethylene glycol double acrylate (PEGDA) hydrogel. Finally

an efficient and rapid processing of hydrogel cell scaffolds was realized experimentally and the diameter of hydrogel tubes was 8

m. This technique can remarkably improve the efficiency of femtosecond laser processing

thus has great potential in many applications such as biological culture and chemical analyses.

关键词

Keywords

references

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ZHANG C C, HU Y L, LI J W, et al.. A rapid two-photon fabrication of tube array using an annular Fresnel lens [J]. Optics Express, 2014, 22(4):3983-3990.

ZHANG C C, HU Y L, LI J W, et al.. An improved multi-exposure approach for high quality holographic femtosecond laser patterning [J]. Applied Physics Letters, 2014, 105(22):221104.

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BRIGO L, URCIUOLO A, GIULITTI S, et al.. 3D high-resolution two-photon crosslinked hydrogel structures for biological studies [J]. Acta Biomaterialia, 2017, 55:373-384.

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