Micro-droplet split digital microfluidic device with fan-shaped electrode

Li-guo CHEN; Zhao-long WANG; Xiong-heng BIAN

doi:10.3788/OPE.20192709.1919

您当前的位置：

首页 >

文章列表页 >

Micro-droplet split digital microfluidic device with fan-shaped electrode

更新时间：2020-08-13

- Micro-droplet split digital microfluidic device with fan-shaped electrode
- Optics and Precision Engineering Vol. 27, Issue 9, Pages: 1919-1925(2019)
- 作者机构：
  
  苏州大学机器人与微系统研究中心，江苏苏州 215021
- 作者简介：
- 基金信息：
- DOI：10.3788/OPE.20192709.1919
  CLC： TG494;TP24
- Received：15 April 2019，
  
  Accepted：10 June 2019，
  
  Published：15 September 2019
- 稿件说明：
移动端阅览
Li-guo CHEN, Zhao-long WANG, Xiong-heng BIAN. Micro-droplet split digital microfluidic device with fan-shaped electrode[J]. Optics and precision engineering, 2019, 27(9): 1919-1925.
DOI：

Li-guo CHEN, Zhao-long WANG, Xiong-heng BIAN. Micro-droplet split digital microfluidic device with fan-shaped electrode[J]. Optics and precision engineering, 2019, 27(9): 1919-1925. DOI： 10.3788/OPE.20192709.1919.

摘要

针对目前液滴在方形电极上分离存在的成功率低，分离后的子液滴体积误差大等问题，本文提出了一种扇形电极结构的数字微流控芯片。在分析液滴在方形电极上分离的影响因素后，结合半月形电极、哑铃状电极和弓形电极的优点设计了扇形电极。与传统分离方式相比，新型芯片在分离前能够调整液滴的初始位置，分离过程中能保证液滴平稳收缩，从而提高分离的成功率和精度。最后使用去离子水作为实验对象，对扇形芯片的分离效果进行了实验验证。结果表明：使用扇形电极在不同极板间距下分离液滴的成功率均高于传统电极，并且分离后的子液滴平均误差在±2%以内，变异系数低至1.83%，通过减少分离电极的尺寸还能进一步提高分离精度。实验数据证明了扇形分离电极数字微流控芯片能够提高分离的成功率和精度。

Abstract

To address the low success rate of droplet separation and the inaccurate daughter droplet volume on the square electrode

a digital microfluidic chip with fan-shaped electrode was proposed and its separation effect was studied. After analyzing the factors affecting droplet separation on the square electrode

the fan-shaped electrode was designed in combination with the advantages of crescent electrodes

dumbbell electrode

and bow electrodes. Compared with traditional separation

the novel chip can adjust the initial position of the droplets before separation to ensure the smooth shrinkage of the droplet during the separation process and improve the success rate and precision of the droplet volume. Deionized water was used as the experimental object to verify the separation effect of the novel chip. The results show that the success rates of droplet separation at different channel heights on novel electrodes are higher than that on conventional electrodes. The average error of daughter droplets is controlled at ±2%

and the coefficient of variation is as low as 1.83%. The separation accuracy can be further improved by reducing the size of the separation electrodes. The experimental results indicate that the separation success rate and splitting precision on digital microfluidic chip with fan-shaped electrode was significantly improved.

关键词

Keywords

references

叶雄英, 徐文晓, 谢帅, 等.面向航天医学应用的体液预处理仪研制[J].光学精密工程, 2017, 25(8): 2083-2089.

YE X Y, XU W X, XIE SH, et al . Development of a body fluids pretreatment instrument for aerospace medicine[J]. Opt. Precision Eng. , 2017, 25(8): 2083-2089. (in Chinese)

徐可欣, 陈小龙, 栗大超, 等.基于微流控和酶比色的微创血糖连续检测仪[J].光学精密工程, 2018, 26(11): 2615-2622.

XU K X, CHEN X L, LI D CH, et al . Minimally invasive continuous blood glucose monitor based on microfluidic and enzyme colorimetric technologies[J]. Opt. Precision Eng. , 2018, 26(11): 2615-2622. (in Chinese)

MARK D, HAEBERLE S, ROTH G, et al . Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications[J]. Chemical Society Reviews , 2010, 39(3): 1153-1182.

FOUILLET Y, JARY D, CHABROL C, et al . Digital microfluidic design and optimization of classic and new fluidic functions for lab on a chip systems[J]. Microfluidics and Nanofluidics , 2008, 4(3): 159-165.

JEBRAIL M J, BARTSCH M S, PATEL K D. Digital microfluidics: a versatile tool for applications in chemistry, biology and medicine[J]. Lab on a Chip , 2012, 12(14): 2452-2463.

TEH S Y, LIN R, HUNG L H, et al . Droplet microfluidics[J]. Lab on a Chip , 2008, 8(2): 198-220.

CHOI K, NG A H C, FOBEL R, et al . Digital microfluidics[J]. Annual Review of Analytical Chemistry , 2012, 5(8):413-440.

ROSE D. Microdispensing technologies in drug discovery[J]. Drug Discovery Today , 1999, 4(9): 411-419.

REN H, FAIR R B, POLLACK M G. Automated on-chip droplet dispensing with volume control by electro-wetting actuation and capacitance metering[J] . Sensors and Actuators B: Chemical , 2004, 98(2/3): 319-327.

NIKAPITIYA N Y J B, NAHAR M M, MOON H. Accurate, consistent, and fast droplet splitting and dispensing in electrowetting on dielectric digital microfluidics[J]. Micro and Nano Systems Letters , 2017, 5(1): 1-10.

DONG C, JIA Y W, GAO J, et al . A 3D microblade structure for precise and parallel droplet splitting on digital microfluidic chips[J]. Lab on a Chip , 2017, 17(5): 896-904.

SONG J H, EVANS R, LIN Y Y, et al . A scaling model for electrowetting-on-dielectric microfluidic actuators[J]. Microfluidics and Nanofluidics , 2009, 7(1): 75-89.

CHO S K, MOON H, KIM C J. Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits[J]. Journal of Microelectromechanical Systems , 2003, 12(1): 70-80.

BIAN X H, CHEN L G, XU X W. A novel crescent electrode for droplet splitting in digital microfluidic[C]. 2015 IEEE 10th Conference on Industrial Electronics and Applications (ICIEA), 2015: 2036-2039. https://www.researchgate.net/publication/308817388_A_novel_crescent_electrode_for_droplet_splitting_in_digital_microfluidic

陈建锋.新型EWOD数字微流控芯片研究[D].上海: 复旦大学, 2014. http://cdmd.cnki.com.cn/Article/CDMD-10246-1015410944.htm

CHEN J F. Study of Novel Digital Microfluidic Chips Based on EWOD [D]. Shanghai: Fudan University, 2014. (in Chinese)

Views

145

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Droplet motion between closed and open regions on digital microfluidic chips

Micro-droplet driven digital mirofluidics device with crescent electrode

Related Author

He WANG

Liguo CHEN

XU Xiao-wei

CHEN Li-guo

SUN Li-ning

Related Institution

School of Mechanical and Electrical Engineering， Soochow University

Mechanical Engineering Department， Henan University of Engineering

苏州大学机器人与微系统研究中心

AI问答

Address：No.3888 Dong Nanhu Road, Changchun, Jilin, China Postal code：130033
Tel：0431-86176855 Email：gxjmgc@ciomp.ac.cn
Technical support is provided by Beijing Founder electronics co., LTD 吉ICP备11002662号-17 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰