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1. 西安交通大学 机械工程学院, 陕西 西安 710049
2. 国家微检测系统工程技术研究中心,陕西 西安 710069
收稿日期:2005-01-14,
修回日期:2005-02-08,
网络出版日期:2005-04-30,
纸质出版日期:2005-04-30
移动端阅览
王朝晖, 李 莉, 李引生, 等. 基于遗传算法的生物组织图像最佳挖取点寻优[J]. 光学精密工程, 2005,13(2):231-236.
WANG Chao-hui, LI Li, LI Yin-sheng, et al. Seeking of tissue image digging point method based on genetic-arithmetic[J]. Optics and precision engineering, 2005, 13(2): 231-236.
生物组织微阵列芯片的制备过程中
需要从包埋有生物组织的蜡块中挖取一块直径为0.5~1.5 mm的组织蜡柱。为了实现自动化作业
研究了基于数字图像处理的组织蜡柱最佳挖取点计算机寻优策略。确定了问题的数学描述为在选定组织图像区域中寻找最大内切圆的圆心
提出了基于遗传算法的寻优算法。重点探讨了坐标点编码
参数选取和遗传操作方法等。研究了个体适应度快速计算方法
初始种群选择等算法改进方案。经过实际编程反复数次实验
结果表明迭代60次算法完全收敛
证明其搜索速度和稳定性都比较好
完全满足自动化作业的在线计算要求。
For tissue-micro-array manufacture automatization
the fitness point seeking in the wax where the tissue sample to be picked up was studied. Based on digital image of tissue
the mathematical model of seeking was described as seeking the biggest inscribed circle center in the tissue area. The seeking method based on genetic-arithmetic was researched
including the code principle
parameters selection and the implementing method. The arithmetic improvement consists of fitness calculation and initialization selection
etc. The results of theory analysis and experiment prove that this arithmetic is effective and useful to fulfill the on-line manipulation.
. 杨琳,李锦毅,郑华川. 组织微阵列/芯片技术及其在肿瘤病理研究中的应用[J]. 中国实验诊断学,2002,(4):267-269. YANG L, LI J Y, ZHENG H CH. Tissue microarray/chip technique and its application in pathology of tumors[J].Chinese Journal of Laboratory Diagnosis,2002,(4):267-269.(in Chinese)
. 茹晓荣. 组织微阵列技术及其应用[J]. 国外医学·生理、病理科学与临床分册, 2004,24(1):104-107. RU X R. Tissue micro array technology and application[J]. Foreign Medical Sciences ·Section of Pathophysiology and Clinical Medicine, 2004,24(1):104-107.(in Chinese)
. 蒋庄德,王朝晖. 生物组织微阵列自动制备仪及其控制方法 . 发明专利,专利申请号:200410073180.2. JIANG ZH D,WANG CH H. Tissue microarray auto-manufacturer and control method . Invent Patent, 200410073180.2.(in Chinese)
. 王小平,曹立明.遗传算法:理论、应用与软件实现[M]. 西安:西安交通大学出版社,2002. WANG X P, CAO L M. Genatic-arithmetic: theory, application and software implement[M]. Xi'an: Xi'an Jiaotong University Press, 2002. (in Chinese)
. 李和平,李德华,朱洲,等. 基于遗传算法的结构光条纹中心检测方法[J]. 光学 精密工程,2004,12(1):82-87. LI H P, LI D H, ZHU ZH, et al.Detection of structured light strip center line based on genetic algorithm[J].Optics and Precision Engineering, 2004, 12 (1):82-87.(in Chinese)
. 邢婉丽,程京.生物芯片技术[M]. 北京:清华大学出版社,2004. XING W L, CHENG J. Biochip technology[M].Beijing:Tsinghua University Press,2004.(in Chinese)
. 章毓晋. 图像工程.图像理解与计算机视觉[M]. 北京:清华大学出版社,1995. ZHANG Y J. Image engineering[M]. Beijing: Tsinghua University Press,1995.(in Chinese)
. 孙玉芹, 车仁生. 求解最大内切圆的一种新方法[J]. 光学 精密工程,2003,11(2):181-185. SUN Y Q, CHE R SH.Novel method for solving maximum inscribed circle [J].Optics and Precision Engineering, 2003, 11(2):181-185.(in Chinese)
. 蔡弋,黄成伟,李庆祥,等. 基于图像识别的动物纤维细度自动测量系统[J]. 光学 精密工程,2002,10(3):239-242. CAI Y,HUANG CH W,LI Q X,et al. Automatic animal fibre measurement system based on image analysis[J]. Optics and Precision Engineering, 2002, 10(3):239-242.(in Chinese)
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