Axial intensity in a fiber-optic confocal microscope

LIU Yong; CHEN Jia-bi; REN Qiu-shi; WANG Cheng; LI Wan-rong

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Axial intensity in a fiber-optic confocal microscope

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- Axial intensity in a fiber-optic confocal microscope
- Axial intensity in a fiber-optic confocal microscope
- 光学精密工程 2005年13卷第5期页码：608-612
- 作者机构：
  
  1. Optical and Electronic Information Engineering College,University of Shanghai for Science &amp
  2. Institute for Laser Medicine &amp
  3. Technology Shanghai,China,200093
  4. Bio-photonics,Shanghai Jiaotong University Shanghai,China,200030
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 收稿日期：2005-03-16，
  
  修回日期：2005-06-27，
  
  网络出版日期：2005-10-30，
  
  纸质出版日期：2005-10-30
- 稿件说明：
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LIU Yong, CHEN Jia-bi, REN Qiu-shi, 等. Axial intensity in a fiber-optic confocal microscope[J]. 光学精密工程, 2005,13(5):608-612.

LIU Yong, CHEN Jia-bi, REN Qiu-shi, et al. Axial intensity in a fiber-optic confocal microscope[J]. Optics and precision engineering, 2005, 13(5): 608-612.
LIU Yong, CHEN Jia-bi, REN Qiu-shi, 等. Axial intensity in a fiber-optic confocal microscope[J]. 光学精密工程, 2005,13(5):608-612. DOI：

LIU Yong, CHEN Jia-bi, REN Qiu-shi, et al. Axial intensity in a fiber-optic confocal microscope[J]. Optics and precision engineering, 2005, 13(5): 608-612. DOI：

摘要

A fiber-optic confocal microscope has been analyzed by Fourier optics.It is found that the detected light intensity has three parts

each of which is depennted on the coupled lens

the detective lens

and the part comprised of the fiber and the microprobe.The simulated results show that the less the value of the parameter

which is dependent on the fiber and microprobe

the higher the axial resolution of the system is. For the case

→∞

the axial resolution is zero

which is corresponding to the conventional microscope.as

≤1

the axial resolution changes slightly

and is close to the optimal value

which is corresponding to the perfect confocal microscope.when the reflective loss takes place at the end of fiber

the contrast of axial intensity will decrease.All that will help the design of endoscope with confocal microscope at cellular level.

Abstract

A fiber-optic confocal microscope has been analyzed by Fourier optics.It is found that the detected light intensity has three parts

each of which is depennted on the coupled lens

the detective lens

and the part comprised of the fiber and the microprobe.The simulated results show that the less the value of the parameter

which is dependent on the fiber and microprobe

the higher the axial resolution of the system is. For the case

→∞

the axial resolution is zero

which is corresponding to the conventional microscope.as

≤1

the axial resolution changes slightly

and is close to the optimal value

which is corresponding to the perfect confocal microscope.when the reflective loss takes place at the end of fiber

the contrast of axial intensity will decrease.All that will help the design of endoscope with confocal microscope at cellular level.

关键词

Keywords

references

. SABHARWAL Y S,ROUSE A R.Slit-scanning confocal microendoscope for high-resolution in vivo imaging[J].Appl.Opt.,1999,38:7133-7144.

. KNITTEL J.Endoscope-compatible confocal microscope using a gradient index-lens system[J].Opt.Commu,2001,188:267-273

. GMITRO A F.Confocal microscopy through a fiber-optic imaging bundle[J].Opt.lett.,1993,18:565-567

. SUNG K B.Near real time in vivo fiber optic confocal microscopy:sub-cellular structure resolved[J]. J.Micros,2002,207:137-145.

. WU CH Q.Optical waveguide theory[M].Tsinghua University press,:80-82.

. GU M,GAN X,SHEPPARD C J P.Three-dimensional coherent transfer functions in fiber-optical confocal scanning microscopes[J].J.Opt.Soc.A.,1991,7:1019-1025.

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