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上海大学理学院2. 上海交通大学生命科学技术学院3. 上海交通大学微纳科学技术研究院4. 中科院上海微系统与信息技术研究所 纳米技术研究室5. 上海交通大学激光与光子生物医学研究所
收稿日期:2008-10-29,
修回日期:2008-12-08,
网络出版日期:2009-10-20,
纸质出版日期:2009-10-20
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邢玉梅,惠春,徐爱兰,李刚,赵建龙,任秋实. 多通道柔性神经微电极加工工艺研究[J]. 光学精密工程, 2009,17(10):2465-2472
Study on microfabrication technology of multichannel flexible neural microelectrodes[J]. Optics and precision engineering, 2009, 17(10): 2465-2472.
目的:设计并制作多通道柔性神经微电极,对微电极的加工工艺进行研究。方法:采用一种新型的柔性聚合物材料——聚对二甲苯(parylene C)作为微电极的基底和绝缘材料,借助微细加工技术,制作柔性神经微电极。结果:利用上述方法制作了36通道(按6×6矩阵排列)的柔性神经微电极,微电极的尺寸分别为150m(圆形)和150m×150m(方形),电极引线线宽为30m。无论微电极为圆形或方形,表面均平整光滑、轮廓清晰。电学性能测试结果表明:1kHz时微电极的阻抗仅为7k左右,且随着频率的增加,阻抗逐渐降低,呈明显高通特性。结论:微电极加工质量较好,电学性能优良。实现了微电极和柔性基底的集成,有利于高效率批量制作。为视觉假体中柔性神经接口的研制奠定基础。
Objective: Multichannel flexible neural microelectrodes were designed and fabricated. The fabrication process of microelectrodes was studied. Method: A microfabrication technology was introduced to manufacture flexible microelectrodes based on a new flexible substrate material
parylene C
due to its excellent electrical insulating
mechanical and biocompatible performances. Result: A 36 channel flexible neural microelectrode was fabricated
arranging in a 6×6 square grid pattern. The size of microelectrode was 150m (circular) and 150m×150m (squre)
respectively. The line width of metal traces was 30m. It was found that the surface of microelectrode was smooth and the outline of microelectrode was distinct. The impedance of microelectrode was only 7k or so
and reduced as frequency increasing
showing a high-pass behavior. Conclusion: The microelectrodes and flexible substrate were integrated by the microfabrication technology. Fabricated microelectrodes had nice quality and good electrical property
which was suitable for the application in retinal prostheses.
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