光学相干层析术无损检测血糖的测量效果评价

许全盛; 冯曙; 叶大田

doi:10.3788/OPE.20101812.2688

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光学相干层析术无损检测血糖的测量效果评价

信息科学 | 更新时间：2020-08-12

- 光学相干层析术无损检测血糖的测量效果评价
- Evaluation of non-invasive detection of blood glucose using OCT
- 光学精密工程 2010年18卷第12期页码：2688-2694
- 作者机构：
  
  清华大学深圳研究生院生物医学工程研究中心, 广州深圳 518055
- 作者简介：
- 基金信息：
  
  广东省科技计划资助项目(No.2008B030303055)()
- DOI：10.3788/OPE.20101812.2688
  中图分类号： TP391;R814.42
- 收稿日期：2009-12-01，
  
  修回日期：2010-03-12，
  
  网络出版日期：2010-12-25，
  
  纸质出版日期：2010-12-25
- 稿件说明：
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许全盛, 冯曙, 叶大田. 光学相干层析术无损检测血糖的测量效果评价[J]. 光学精密工程, 2010,18(12): 2688-2694

XU Quan-sheng, FENG Shu, YE Da-tian. Evaluation of non-invasive detection of blood glucose using OCT[J]. Editorial Office of Optics and Precision Engineering, 2010,18(12): 2688-2694
许全盛, 冯曙, 叶大田. 光学相干层析术无损检测血糖的测量效果评价[J]. 光学精密工程, 2010,18(12): 2688-2694 DOI： 10.3788/OPE.20101812.2688.

XU Quan-sheng, FENG Shu, YE Da-tian. Evaluation of non-invasive detection of blood glucose using OCT[J]. Editorial Office of Optics and Precision Engineering, 2010,18(12): 2688-2694 DOI： 10.3788/OPE.20101812.2688.

摘要

为改进现有光学相干层析术(OCT)无损检测血糖评价方法的不足

提出将OCT信号斜率相对变化量和相对标准误差相结合来评价测量结果

并同时得到血糖的理论测量精度。首先

分析了OCT系统共焦函数对测量结果的影响及OCT信号斜率相对误差的计算方法

然后

通过对3只新西兰白兔进行活体实验来评价OCT无损检测血糖的测量结果。在测量血糖引起的OCT信号斜率相对变化量的同时

对OCT信号斜率相对误差也进行了计算

从而获得血糖的理论测量精度。新西兰白兔活体实验表明

线性度较好的拟合区间下OCT信号斜率相对变化量和相对误差分别为(3.7%)/mmol和0.068

(3.4%)/mmol和0.026

(0.93%)/mmol和0.019

血糖理论测量精度分别为3.7 mmol

1.5 mmol和4.1 mmol。OCT信号斜率的相对变化量和相对标准误差相结合的评价方法能更有效地提高血糖理论测量精度

而且拟合区间越大

血糖的测量精度越高。

Abstract

To improve the evaluation method of non-invasive detection of blood glucose by Optical Coherence Tomography(OCT)

a method combining the relative variance of OCT signal slope with the relative standard error was presented to evaluate the measurement effect and to obtain the theoretical precision of blood glucose detection. Firstly

the effect of the OCT confocal function on the blood glucose detection and the computing method of the relative error of OCT signal slope were given. Then

the relative variance and standard error of the OCT signal slope via a vivo experiment on 3 New Zealand rabbits were carried out to evaluate the non-invasive detection of blood glucose. Obtained results indicate that the relative variance and standard error of OCT signal slope are (3.7 %)/mmol & 0.068

(3.4 %)/mmol & 0.026

(0.93 %)/mmol & 0.019

respectively

and the theoretical measuring precision of blood glucose detection are 3.7 mmol

1.5 mmol and 4.1 mmol

respectively. It concludes that the the evaluation method of combining the relative variance and standard error of OCT signal slope can greatly improve the theoretical measuring precision of blood glucose detection

and the larger the fitting interval is

the higher the measuring precision is.

关键词

Keywords

references

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