结合近红外光谱法的肝血流参数测量

张晓枫; 刘光达; 辛桂杰; 焦阳; 徐国忠

doi:10.3788/OPE.20122010.2140

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结合近红外光谱法的肝血流参数测量

现代应用光学 | 更新时间：2020-08-12

- 结合近红外光谱法的肝血流参数测量
- Measurement of liver blood flow parameters combined with near-infrared spectroscopy
- 光学精密工程 2012年20卷第10期页码：2140-2146
- 作者机构：
  
  1. 吉林大学仪器科学与电气工程学院,吉林长春,130061
  2. 吉林大学第一医院,吉林长春,130061
  3. 长春理工大学生命科学技术学院,吉林长春,130022
- 作者简介：
- 基金信息：
  
  吉林省科技厅资助项目(No.20120328)()
- DOI：10.3788/OPE.20122010.2140
  中图分类号： R318;O657.33
- 收稿日期：2012-03-07，
  
  修回日期：2012-05-15，
  
  纸质出版日期：2012-10-10
- 稿件说明：
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张晓枫, 刘光达, 辛桂杰, 焦阳, 徐国忠. 结合近红外光谱法的肝血流参数测量[J]. 光学精密工程, 2012,20(10): 2140-2146

ZHANG Xiao-feng, LIU Guang-da, XIN Gui-jie, JIAO Yang, XU Guo-zhong. Measurement of liver blood flow parameters combined with near-infrared spectroscopy[J]. Editorial Office of Optics and Precision Engineering, 2012,20(10): 2140-2146
张晓枫, 刘光达, 辛桂杰, 焦阳, 徐国忠. 结合近红外光谱法的肝血流参数测量[J]. 光学精密工程, 2012,20(10): 2140-2146 DOI： 10.3788/OPE.20122010.2140.

ZHANG Xiao-feng, LIU Guang-da, XIN Gui-jie, JIAO Yang, XU Guo-zhong. Measurement of liver blood flow parameters combined with near-infrared spectroscopy[J]. Editorial Office of Optics and Precision Engineering, 2012,20(10): 2140-2146 DOI： 10.3788/OPE.20122010.2140.

摘要

针对常规的色素浓度测量方法存在操作复杂、有创和非连续等问题

研究了基于色素稀释和排泄试验的脉搏光谱分析方法。通过静脉注射吲哚青绿指示剂

选定两特定波长的近红外光作为吲哚青绿色素吸光度测量点

并采用指夹式传感器提取人体指尖末梢血的光谱信号

通过连续记录色素浓度稀释曲线

实现了分离吲哚青绿浓度谱和脉搏血氧吸收光谱的算法。最后分析呈指数衰减规律变化的半对数坐标色素浓度图

完成了色素血浆消失率

和15 min滞留率

等肝血流参数的无创测量。该方法基于Lab-VIEW平台

结合自适应差分阈值法

有效剔除了血红蛋白吸收光谱和基线漂移的干扰

各项参数检测准确率高

值平均测量误差小于0.008。该检测理论和方法既可用于临床肝切除手术的术前、术中和术后的肝储备功能检查

也可为医学研究提供相应的中间测量过程及中间观察变量。

Abstract

A pulse spectroscopic scheme based on dye dilution and an excretion test was developed to overcome the shortcomings of conventional blood dye concentration measuring method in complex operation

invasive treatment and non-continuance. Firstly

Indocyanine Green(ICG) was intravenously injected and a finger clip sensor was used to extract spectral signals of fingertips for a sufferer. Then

by recording the dye dilution curve simultaneously

the algorithm to isolate ICG absorption spectrum from the disturbance of peripheral arterial blood was implemented. Finally

the ICG plasma disappearance rate

15 min retention rate

and other hepatic hemodynamic parameters were deduced by analyzing the semi-logarithmic dye concentration graph. Combining a lab-VIEW software platform with an adaptive differential threshold method

proposed scheme eliminates the interference come from the hemoglobin absorption spectrum and baseline drift

improves the measuring accuracy greatly

and the average measurement error of

is less than 0.008. This method is great value to not only the assessing hepatic functional reserve at pre-operation

intra-operation

post-operation

but also providing a way to monitor some middle variables for clinical research purposes.

关键词

Keywords

references

钱刚,吴宝灵,余海滨,等. 肝脏储备功能检测在肝硬化诊疗中的临床应用[J]. 实用临床医学,2009,10(1):22-24. QIAN G, WU B L, YU H B, et al.. Clinical application of liver functional reserves tests in diagnosis of liver cirrhosis [J]. Practical Clinical Medicine, 2009, 10(1):22-24. (in Chinese)[2] 杨洁.肝脏储备功能评估的临床研究. 安徽:安徽医科大学硕士学位论文,2009. LI J. Clinical Study of Evaluating Liver Functional Reserve.Anhui: Anhui Medical University, 2009. (in Chinese)[3] 唐俊,杜美华,朱俊峰,等. 无创肝血流测定在麻醉监护中的应用[J]. 中国临床医学,2010,17(1):111-114. TANG J, DU M H, ZHU J F, et al.. Non-invasive monitoring of hepatic blood flow in anesthesia practice[J].Chinese Clinical Medicine,2010,17(1):111-114. (in Chinese)[4] MENNO R G, PHILIP C D, LEONARD J V, et al.. Blood volume measurement with indocyanine green pulse spectrophotometry: dose and site of dye administration[J]. Acta Neurochirurgica, 2010,152(2):251-255.[5] 陆森,黄新立,李相成,等. 吲哚氰绿清除试验在半肝切除术中应用的价值[J]. 中国普外基础与临床杂志,2010,17(6):543-546. LU S, HUANG X L, LI X CH, et al.. Effect of detection of ICG R15 during hemihepatectomy for patients with primary liver carcinoma[J].Chinese Journal of Bases and Clinics in General Surgery,2010,17(6):543-546. (in Chinese)[6] REEKS M, SIMON MJ G, BOER F, et al.. Pulse dye densitometry and indocyanine green plasma disappearance in ASA physical I-II status patients[J]. Anesthesia & Analgesia, 2010,110(2):466-472.[7] MERLE U, SIEG U, STREMMEL W, et al.. Sensitivity and specificity of plasma disappearance rate of indocyanine green as a prognostic indicator in acute liver failure [J]. BMC Gastroenterology, 2009,9(91):1-7.[8] 陈星旦. 近红外光谱无创生化检验的可能性[J]. 光学精密工程,2008,16(5):760-762. CHEN X D. The possibility of noninvasive near-infrared biochemical analysis[J]. Opt. Precision Eng., 2008,16(5):760-762. (in Chinese)[9] 卢启鹏,陈丛,彭忠琦. 自适应滤波在近红外无创生化分析中的应用[J]. 光学精密工程,2012,20(4):873-879. LU Q P, CHEN CH, PENG ZH Q. Application of adaptive filter to noninvasive biochemical examination by near infrared spectroscopy[J]. Opt. Precision Eng., 2012,20(4):873-879. (in Chinese)[10] NOIRI E, KOBAYASHI N, TAKAMURA Y, et al.. Pulse total-hemoglobinometer provides accurate monitoring[J]. Critical Care Medicine, 2005,33(12):2831-2835.[11] KIM J G, XIA M, LIU H. Extinction coefficients of hemoglobin for near-infrared spectroscopy of tissue[J].Engineering in Medicine and Biology Magazine,2005,24(2):118-121.[12] AOYAGI T, MIYASAKA K. The theory and application of pulse spectrophotometry[J]. Anesthesia & Analgesia, 2002,94(1):93-95.[13] TENG X F, ZHANG Y T. Blood oxygen saturation measurements [J]. Wiley Encyclopedia of Biomedical Engineering, 2006,4(14):605-612.[14] SCOTT P. Optical Absorption of Indocyanine Green (ICG).(1998-3-4).http://omlc.ogi.edu/spectra/icg/index.html[15] SCOTT P. Optical Absorption of Hemoglobin.(1999-11-15).http://omlc.ogi.edu/spectra/hemoglobin/index.html[16] CHANTEMELE E B D, KOCH G G, DUVAREILLE M, et al.. Blood volume measurement: the comparison of pulse dye densitometry and Dill and Costill's methods[J]. Life Science, 2006,78(14):1564-1569.[17] OKOCHI O, KANEKO T, SUGIMOTO H, et al.. ICG pulse spectrophotometry for perioperative liver function in hepatectomy[J]. Journal of Surgical, 2002,103(1):109-113.

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