基于轴向振动配粉技术的药物微量配粉

王小鹏; 陈天宁; 李欣欣

doi:10.3788/OPE.20142206.1584

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基于轴向振动配粉技术的药物微量配粉

微纳技术与精密机械 | 更新时间：2020-08-13

- 基于轴向振动配粉技术的药物微量配粉
- Drug quantitative dispensing based on axial vibration microfeeding technology
- 光学精密工程 2014年22卷第6期页码：1584-1589
- 作者机构：
  
  西安交通大学机械工程学院机械结构强度与振动国家重点实验室,陕西西安,710049
- 作者简介：
- 基金信息：
  
  中央高校基本科研业务费专项资金资助项目(3132016351)
- DOI：10.3788/OPE.20142206.1584
  中图分类号： TQ460.6
- 收稿日期：2013-12-11，
  
  修回日期：2014-02-03，
  
  纸质出版日期：2014-06-25
- 稿件说明：
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王小鹏, 陈天宁, 李欣欣. 基于轴向振动配粉技术的药物微量配粉[J]. 光学精密工程, 2014,22(6): 1584-1589

WANG Xiao-peng, CHEN Tian-ning, LI Xin-xin. Drug quantitative dispensing based on axial vibration microfeeding technology[J]. Editorial Office of Optics and Precision Engineering, 2014,22(6): 1584-1589
王小鹏, 陈天宁, 李欣欣. 基于轴向振动配粉技术的药物微量配粉[J]. 光学精密工程, 2014,22(6): 1584-1589 DOI： 10.3788/OPE.20142206.1584.

WANG Xiao-peng, CHEN Tian-ning, LI Xin-xin. Drug quantitative dispensing based on axial vibration microfeeding technology[J]. Editorial Office of Optics and Precision Engineering, 2014,22(6): 1584-1589 DOI： 10.3788/OPE.20142206.1584.

摘要

针对轴向振动配粉技术在植入式可降解缓释给药系统微量配粉中的应用，搭建了轴向振动配粉实验台。采用毛细玻璃漏斗和圆锥状塑料吸头作为配粉管，研究两者稳定流动的振动幅值区间，讨论了振动频率对稳定出粉起始幅值、振动幅值对出粉流量及出粉流量稳定性的影响。结果表明：采用圆锥状塑料吸头作为配粉管的配粉过程更稳定，并且具有良好的抗堵性能；振动频率越大，实现配粉需要的起始激振幅度越小；在固定激振频率下，出粉流量随振幅先增大后减小，且管体中粉体处于充分流动状态；在激振频率为50 Hz，150 Hz，振幅为200~300 μm和35~50 μm时，可以得到最大且不随振幅改变的稳定出粉流量。实验论证了轴向振动配粉技术可以实现微量粉体的稳定、精确配给。

Abstract

For application of the axial vibration micro feeding technology to the quantitative dispensing of an implant control releasing drug micro system

an experimental apparatus based on the axial vibration method was set up. By using a glass capillary hopper and a conical plastic-tip as the dispending tubes

the vibration amplitude between both dispending tubes was researched and the influences of quantitative dispensing control parameters on the starting vibration amplitude

powder flow rate and the powder flow stability were discussed. The results show that the conical plastic-tip is a better dispensing tube with stable dispensing and good resistance to plugging. The higher the frequency

the lower the starting vibration amplitude needed to achieve desired starting feeding. At a constant excitation frequency

the flowing powder in the tube increases with the flow rate first

and then decreases to a stable value

meanwhile being a full flow state. Under both conditions with the excitation frequencies of 50 Hz

150 Hz and the amplitude between 200-300 μm and 35-50 μm

the maximum and stable powder flow rate can be obtained. It concludes that the axial vibration micro feeding technology can achieve stable

accurate dispensing of the drug powder.

关键词

Keywords

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