光电容积脉搏波无创测量人体血液成分的评估

刘瑾; 蔡子晋; 张紫杨; 孙迪; 王文

doi:10.3788/OPE.20162406.1264

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光电容积脉搏波无创测量人体血液成分的评估

现代应用光学 | 更新时间：2020-08-13

- 光电容积脉搏波无创测量人体血液成分的评估
- Evaluation on noninvasive blood components measurement based on photolepthysmography
- 光学精密工程 2016年24卷第6期页码：1264-1271
- 作者机构：
  
  1. 天津大学精密测试技术及仪器国家重点实验室天津,300072
  2. 天津市计量监督检测科学研究院天津,300192
- 作者简介：
- 基金信息：
  
  国家863高技术研究发展计划资助项目（No.2012AA022602）();国家自然科学基金资助项目（No.60938002）()
- DOI：10.3788/OPE.20162406.1264
  中图分类号： O433.1;O657.33
- 收稿日期：2016-03-22，
  
  修回日期：2016-04-12，
  
  纸质出版日期：2016-06-25
- 稿件说明：
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刘瑾, 蔡子晋, 张紫杨等. 光电容积脉搏波无创测量人体血液成分的评估[J]. 光学精密工程, 2016,24(6): 1264-1271

LIU Jin, CAI Zi-jin, ZHANG Zi-yang etc. Evaluation on noninvasive blood components measurement based on photolepthysmography[J]. Editorial Office of Optics and Precision Engineering, 2016,24(6): 1264-1271
刘瑾, 蔡子晋, 张紫杨等. 光电容积脉搏波无创测量人体血液成分的评估[J]. 光学精密工程, 2016,24(6): 1264-1271 DOI： 10.3788/OPE.20162406.1264.

LIU Jin, CAI Zi-jin, ZHANG Zi-yang etc. Evaluation on noninvasive blood components measurement based on photolepthysmography[J]. Editorial Office of Optics and Precision Engineering, 2016,24(6): 1264-1271 DOI： 10.3788/OPE.20162406.1264.

摘要

为了评估光电容积脉搏波法在人体血液主要成分检测方面的精度水平，基于朗伯比尔定律及简化的光电容积脉搏波法测量模型，给出了物质成分测量的极限分辨浓度公式。对公式中的三个要素，即人体测量时的光强信噪比、光程、被测物质的摩尔消光系数进行了评估，获得了理论上光电脉搏波法对血红蛋白、白蛋白、血糖的极限分辨浓度。评估结果表明，光电容积脉搏波法可以测量的血红蛋白、白蛋白和血糖的极限分辨浓度水平分别约为100 mg／dL，5000 mg／dL以及10 000 mg／dL。将该评价结果与现阶段临床需要的检测精度进行对比，可知光电容积脉搏波法能够满足需求，有望实现对血红蛋白的无创检测。

Abstract

To evaluate the precision level of Photolepthysmography(PPG) in detection of the main components of human blood

the formula for the limit resolution concentration of material components measurement was given based on the Lambert-Beer's Law and simplified measurement model of PPG. Through the evaluation of three elements-Signal-to-Noise Ratio(SNR) of light intensity

optical path and the molar extinction coefficient of the blood components during human measurements

the theoretical limit resolution concentrations of the pulse oximeter signal method for hemoglobin

albumin and blood glucose were obtained. The evaluation result shows that the limit resolution concentration levels of hemoglobin

albumin and blood glucose which can be measured through PPG are respectively 100 mg/dL

5000 mg/dL and 10 000 mg/dL. The comparison of the evaluation result with the detection precision needed on clinic at the present stage indicates that the PPG can meet the demands for the non-invasive detection of hemoglobin.

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Keywords

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