生物组织的太赫兹数字全息成像

郭力菡; 王新柯; 张岩

doi:10.3788/OPE.20172503.0611

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生物组织的太赫兹数字全息成像

现代应用光学 | 更新时间：2020-07-07

- 生物组织的太赫兹数字全息成像
- Terahertz digital holographic imaging of biological tissues
- 光学精密工程 2017年25卷第3期页码：611-615
- 作者机构：
  
  首都师范大学物理系, 北京 100048
- 作者简介：
  
  [ "郭力菡 (1991-), 女, 河南新乡人, 硕士, 2014年于信阳师范学院获得学士学位, 主要从事生物组织太赫兹成像方面的研究。E-mail:2140602023@cnu.edu.cn" ]
  王新柯 (1982-), 男, 北京人, 博士, 副教授, 2004年、2007年于首都师范大学分别获得学士、硕士学位, 2011年于哈尔滨工业大学获得博士学位, 主要从事太赫兹成像等方面的研究。E-mail:wxk82721@163.com WANG Xin-ke, E-mail:wxk82721@163.com
- 基金信息：
  
  国家自然科学基金资助项目(11474206)
- DOI：10.3788/OPE.20172503.0611
  中图分类号： O433.4;TH773
- 收稿日期：2016-10-13，
  
  录用日期：2016-12-5，
  
  纸质出版日期：2017-03-25
- 稿件说明：
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郭力菡, 王新柯, 张岩. 生物组织的太赫兹数字全息成像[J]. 光学精密工程, 2017,25(3):611-615.

Li-han GUO, Xin-ke WANG, Yan ZHANG. Terahertz digital holographic imaging of biological tissues[J]. Optics and precision engineering, 2017, 25(3): 611-615.
郭力菡, 王新柯, 张岩. 生物组织的太赫兹数字全息成像[J]. 光学精密工程, 2017,25(3):611-615. DOI： 10.3788/OPE.20172503.0611.

Li-han GUO, Xin-ke WANG, Yan ZHANG. Terahertz digital holographic imaging of biological tissues[J]. Optics and precision engineering, 2017, 25(3): 611-615. DOI： 10.3788/OPE.20172503.0611.

摘要

太赫兹辐射具有低光子能量和较高的透射性，并对水分子等极性物质反应敏感，因此太赫兹数字全息成像法可以快速准确地获取生物组织信息。本文利用太赫兹数字全息成像系统对猪肉和羊肉组织切片进行测量，采用菲涅耳反衍射方法对实验结果进行优化，选取0.9 THz分量的振幅图像进行分析。通过计算组织的吸光度获取0.9 THz吸光度图像。实验结果显示，肌肉组织的吸光度均在8 cm

-1

以上，脂肪组织的吸光度不超过4 cm

-1

。采用主成分分析方法获得吸光度得分图并进行重建，从重建结果中可以清晰区分生物组织的不同区域。由此表明，太赫兹数字全息成像技术能够直接获取生物组织的二维信息，探测时间短、效率高，在生物检测领域具有广阔的应用前景。

Abstract

Terahertz (THz) radiation has low photon energy and high transmissivity and is sensitive to polar materials such as hydrone. Thus

THz digital holographic imaging method has the capacity to acquire biological tissue information rapidly and correctly. Herein

tissue slices of pork and mutton were measured with THz digital holographic imaging system. The experimental images were optimized with method of Fresnel diffraction and the amplitude image of 0.9 THz component was selected for analysis. 0.9 THz absorbance image was acquired by calculating tissular absorbance. The results show that all the absorbance of muscle tissue is above 8 cm

-1

while that of adipose tissue is less than 4 cm

-1

. Absorbance score plot is retrieved with Principle Component Analysis (PCA) and the different regions in biological tissue can be distinguished clearly from the results of reestablishment

which show that THz digital holographic imaging technology is able to acquire two-dimensional information of biological tissue with the advantages of short detection time and high efficiency. Thus

it has broad application prospects in the field of biological detection.

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references

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