水凝胶支架的飞秒激光全息加工

潘登; 李家文; 杨亮; 胡衍雷; 吴东; 黄文浩; 褚家如

doi:10.3788/OPE.20172509.2277

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水凝胶支架的飞秒激光全息加工

现代应用光学 | 更新时间：2020-08-13

- 水凝胶支架的飞秒激光全息加工
- Femtosecond laser holograpic fabrication of hydrogel cell scaffold
- 光学精密工程 2017年25卷第9期页码：2277-2282
- 作者机构：
  
  中国科学技术大学精密机械与精密仪器系, 安徽合肥 230026
- 作者简介：
  
  [ "潘登(1996-), 男, 安徽六安人, 2012年于北京科技大学获得学士学位, 主要从事飞秒激光加工和光场调控方面的研究.E-mail:dpan@mail.ustc.edu.cn" ]
  李家文(1971-), 男, 安徽舒城人, 博士, 副教授, 2011年于中国科学技术大学获得博士学位, 2011年至2013年为中国科学技术大学博士后, 2015年至2016年为美国加州大学圣地亚哥分校(UCSD)纳米工程系访问学者, 主要从事飞秒激光加工技术、三维生物打印技术及应用、微纳功能表面及功能器件、结构色机理及加工方法等方面的研究.E-mail:jwl@ustc.edu.cn LI Jia-wen, E-mail:jwl@ustc.edu.cn
- 基金信息：
  
  国家自然科学基金资助项目(51675503);国家自然科学基金资助项目(61475149);国家自然科学基金资助项目(51405464);国家自然科学基金资助项目(61675190);国家自然科学基金资助项目(51605463);中央高校基本研究经费资助项目(WK2480000002);中国博士后科学基金资助项目(2016M590578);中国博士后科学基金资助项目(2016M602027);中科院仪器研制项目(YZ201566)
- DOI：10.3788/OPE.20172509.2277
  中图分类号： TN249;TH691.9
- 收稿日期：2017-06-05，
  
  录用日期：2017-6-27，
  
  纸质出版日期：2017-09-25
- 稿件说明：
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潘登, 李家文, 杨亮, 等. 水凝胶支架的飞秒激光全息加工[J]. 光学精密工程, 2017,25(9):2277-2282.

Deng PAN, Jia-wen LI, Liang YANG, et al. Femtosecond laser holograpic fabrication of hydrogel cell scaffold[J]. Optics and precision engineering, 2017, 25(9): 2277-2282.
潘登, 李家文, 杨亮, 等. 水凝胶支架的飞秒激光全息加工[J]. 光学精密工程, 2017,25(9):2277-2282. DOI： 10.3788/OPE.20172509.2277.

Deng PAN, Jia-wen LI, Liang YANG, et al. Femtosecond laser holograpic fabrication of hydrogel cell scaffold[J]. Optics and precision engineering, 2017, 25(9): 2277-2282. DOI： 10.3788/OPE.20172509.2277.

摘要

为了实现以水凝胶为材料的细胞支架快速加工

将计算全息法引入传统的飞秒激光双光子加工中

并对全息图的生成方法和全息图对加工结构的影响进行了研究。首先

根据贝塞尔光波动方程和其透射函数生成贝塞尔光束全息图

分析两种参数对环形结构大小和质量的影响。然后利用生成的全息图加工得到壁厚800 nm、直径为8~15

m不等的水凝胶（PEGDA）圆管结构。最后

实现了基于圆管道的水凝胶细胞支架高效快速加工

支架中圆管道壁厚800 nm、直径为8

m。本文首次将飞秒激光全息加工技术应用于水凝胶三维支架加工

解决了飞秒激光单点加工效率的问题。该技术在生物医学中具有广阔的应用前景。

Abstract

In order to achieve rapid fabrication of hydrogel cell scaffolds

the computer-aided holographic method was employed into the traditional femtosecond laser two-photon processing. The generation of hologram as well as the influence of its parameters on the processed cylinder microstructure was studied. Firstly

Ring-shaped Bessel-beam holograms were generated according to the Bessel light wave equation and its transmission function

of which the parameters' effect on the size and quality of ring structure was analyzed. Then the generated holograms were used to process tubes with a thickness of 0.8

m and diameters from 8

m to 15

m in the polyethylene glycol double acrylate (PEGDA) hydrogel. Finally

an efficient and rapid processing of hydrogel cell scaffolds was realized experimentally and the diameter of hydrogel tubes was 8

m. This technique can remarkably improve the efficiency of femtosecond laser processing

thus has great potential in many applications such as biological culture and chemical analyses.

关键词

Keywords

references

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ZHANG C C, HU Y L, LI J W, et al.. A rapid two-photon fabrication of tube array using an annular Fresnel lens [J]. Optics Express, 2014, 22(4):3983-3990.

ZHANG C C, HU Y L, LI J W, et al.. An improved multi-exposure approach for high quality holographic femtosecond laser patterning [J]. Applied Physics Letters, 2014, 105(22):221104.

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BRIGO L, URCIUOLO A, GIULITTI S, et al.. 3D high-resolution two-photon crosslinked hydrogel structures for biological studies [J]. Acta Biomaterialia, 2017, 55:373-384.

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