基于三维卷积神经网络的低剂量CT肺结节检测

吕晓琪; 吴凉; 谷宇; 张文莉; 李菁

doi:10.3788/OPE.20182605.1211

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基于三维卷积神经网络的低剂量CT肺结节检测

信息科学 | 更新时间：2020-08-13

- 基于三维卷积神经网络的低剂量CT肺结节检测
- Detection of low dose CT pulmonary nodules based on 3D convolution neural network
- 光学精密工程 2018年26卷第5期页码：1211-1218
- 作者机构：
  
  1.内蒙古科技大学信息工程学院, 内蒙古包头 014010
  2.上海大学计算机工程与科学学院, 上海 200444
- 作者简介：
  
  [ "吕晓琪(1963-), 男, 内蒙古包头人, 博士, 教授, 博士生导师, 1984年于内蒙古大学获学士学位, 1989年于西安交通大学获硕士学位, 2003年于北京科技大学获博士学位, 主要从事智能图像处理、医疗信息系统的构建与集成、电子病历及其数据挖掘方面的研究。E-mail:lxiaoqi@imust.edu.cn" ]
  [ "吴凉(1990-), 男, 山东聊城人, 硕士研究生, 2015年于泰山医学院获学士学位, 主要从事X射线成像、模式识别、智能信息处理方面的研究。E-mail:wl202305@126.com" ]
- 基金信息：
  
  国家自然科学基金资助项目(61771266);国家自然科学基金资助项目(61179019);内蒙古自治区自然科学基金资助项目(2015MS0604);内蒙古自治区高等学校科学研究项目(NJZY145);包头市科技计划项目(2015C2006-14)
- DOI：10.3788/OPE.20182605.1211
  中图分类号： TP391.4;R445.3
- 收稿日期：2017-09-04，
  
  录用日期：2017-11-6，
  
  纸质出版日期：2018-05-25
- 稿件说明：
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吕晓琪, 吴凉, 谷宇, 等. 基于三维卷积神经网络的低剂量CT肺结节检测[J]. 光学精密工程, 2018,26(5):1211-1218.

Xiao-qi LÜ, Liang WU, Yu GU, et al. Detection of low dose CT pulmonary nodules based on 3D convolution neural network[J]. Optics and precision engineering, 2018, 26(5): 1211-1218.
吕晓琪, 吴凉, 谷宇, 等. 基于三维卷积神经网络的低剂量CT肺结节检测[J]. 光学精密工程, 2018,26(5):1211-1218. DOI： 10.3788/OPE.20182605.1211.

Xiao-qi LÜ, Liang WU, Yu GU, et al. Detection of low dose CT pulmonary nodules based on 3D convolution neural network[J]. Optics and precision engineering, 2018, 26(5): 1211-1218. DOI： 10.3788/OPE.20182605.1211.

摘要

为提高早期肺癌筛查过程中肺结节的检出率，提出利用三维卷积神经网络进行低剂量CT肺结节检测。首先采用多方向形态学滤波算法对低剂量序列CT图像进行预处理；接着，利用改进三维区域生长与凸包算法相结合进行肺实质分割；然后提取三维候选结节，为了解决卷积神经网络对样本不平衡的敏感问题，对三维候选结节正样本进行旋转和光照处理；最后在不同的网络参数下，对ELCAP数据库中50个序列低剂量肺癌筛查数据进行4组实验。实验结果表明，通过对网络参数的不断优化，准确度、灵敏度、特异度以及ROC曲线的AUC值分别达到了84.6%、88.89%、80.32%及0.924 4。该方法能够正确地对低剂量CT肺结节进行检测，与文献所提出肺结节检测算法相比，准确度、灵敏度和特异度分别平均提高了5.37%、5.6%和10.42%，综合性能较强，可以为肺癌筛查提供有效的帮助。

Abstract

To improve the detection rate of pulmonary nodules in early lung cancer screening

a low-dose CT pulmonary nodule detection algorithm based on 3D convolution neural network was presented. First

the multi-directional morphological filtering algorithm was used to preprocess low-dose sequence CT image. The improved 3D region growth algorithm combined with the convex hull algorithm was used for lung parenchymal segmentation. Then the 3D candidate nodules were routed and illuminated in order to solve the convolution neural network on the sample imbalance sensitive issues. Finally

in situations of different network parameters

four groups of experiments were performed on the 50 sequences of low-dose lung cancer screening data in ELCAP database. The results showed that accuracy

sensitivity

specificity and ROC curve of the AUC values were 84.6%

88.89%

80.32% and 0.924 4 respectively by the constant optimization of network parameters. The proposed algorithm can correctly detect low-dose lung nodules

with the the accuracy

sensitivity

and specificity increased by 5.37%

5.6% and 10.42%

respectively

which is more comprehensive and can provide effective help for lung cancer screening compared with conventional lung nodule detection algorithm.

关键词

Keywords

references

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