采用针-环离子源的集成式高场非对称波形离子迁移谱系统

李华; 云红梅; 杜晓霞; 曾若生; 蒋永荣; 陈真诚

doi:10.3788/OPE.20192706.1255

您当前的位置：

首页 >

文章列表页 >

采用针-环离子源的集成式高场非对称波形离子迁移谱系统

生命科学仪器 | 更新时间：2020-08-13

- 采用针-环离子源的集成式高场非对称波形离子迁移谱系统
- Integrated FAIMS system using needle-ring ion source
- 光学精密工程 2019年27卷第6期页码：1255-1262
- 作者机构：
  
  桂林电子科技大学生命与环境科学学院，广西桂林 541004
- 作者简介：
  
  [ "李华(1978-)，男，湖南郴州人，博士，教授，2001年、2004年于中北大学分别获得学士和硕士学位，2007年于北京理工大学获得博士学位，2010年于清华大学仪器科学与技术博士后流动站出站，主要从事微型生化分析仪器和MEMS等的研究。E-mail：lihua@guet.edu.cn" ]
  [ "云红梅(1993-)，女，陕西延安人，硕士研究生，2016于西北工业大学明德学院获得学士学位，主要从事微型生化分析仪器的研究。E-mail：1358143281@qq.com" ]
- 基金信息：
  
  国家自然科学基金资助项目(61864001);国家自然科学基金资助项目(81873913);国家自然科学基金资助项目(61627807);广西自然科学基金资助项目(2017GXNSFAA198256);广西自然科学基金资助项目(2017GXNSFGA198005);广西自动检测技术与仪器重点实验室主任基金资助项目(YQ18113)
- DOI：10.3788/OPE.20192706.1255
  中图分类号： TP212.3
- 收稿日期：2019-01-17，
  
  录用日期：2019-3-7，
  
  纸质出版日期：2019-06-15
- 稿件说明：
移动端阅览
李华, 云红梅, 杜晓霞, 等. 采用针-环离子源的集成式高场非对称波形离子迁移谱系统[J]. 光学精密工程, 2019,27(6):1255-1262.

Hua LI, Hong-mei YUN, Xiao-xia DU, et al. Integrated FAIMS system using needle-ring ion source[J]. Optics and precision engineering, 2019, 27(6): 1255-1262.
李华, 云红梅, 杜晓霞, 等. 采用针-环离子源的集成式高场非对称波形离子迁移谱系统[J]. 光学精密工程, 2019,27(6):1255-1262. DOI： 10.3788/OPE.20192706.1255.

Hua LI, Hong-mei YUN, Xiao-xia DU, et al. Integrated FAIMS system using needle-ring ion source[J]. Optics and precision engineering, 2019, 27(6): 1255-1262. DOI： 10.3788/OPE.20192706.1255.

摘要

为了实现离子源和高场非对称波形离子迁移谱的其它部分的集成，本文基于PCB工艺设计了一种新型的针-环离子源结构。该结构主要由针电极、环电极、进气底座以及针固定底座组成，针电极采用针尖曲率半径为28

m的不锈钢针作为放电阴极，直径为3 mm、高度为16 mm的铜环作为放电阳极。放电特性实验结果表明：针-环离子源在放电电压-2 kV和-2.8 kV时，分别进入了电晕放电和辉光放电，能够在大气压环境下实现稳定放电。在载气流速为1.5 L/min、方波射频电压幅值为300 V的条件下，两者FAIMS谱图中补偿电压基本相同，且采用针-环离子源和紫外灯离子源所得的FAIMS谱图的电流峰值分别为64 pA和45 pA，由此表明集成式针-环离子源FAIMS系统能够稳定工作，且相比紫外灯离子源集成性更好，电流信号更强。

Abstract

A needle-ring ion source structure based on printed circuit board technology was designed to integrate an ion source with a High-field Asymmetric Ion Mobility Spectrometry (FAIMS) structure

which was composed of a needle electrode

loop electrode

air inflow pedestal

and fixed needle pedestal. A stainless steel needle tip with a diameter of 28

m was used as the cathode

and a copper loop with a diameter of 3 mm and length of 16 mm was used as the anode. A discharge property experiment shows that corona and glow discharges are realized through discharge voltages of -2 kV and -2.8 kV

respectively

proving that the stable discharge state could be obtained in ambient air. Comparing the FAIMS system using a UV-lamp ion source with the FAIMS system using a needle-ring ion source

the compensation voltages in the FAIMS spectrum are nearly the same under the conditions of a carrier gas flow rate of 1.5 L/min and a high-field rectangular radio peak-to-peak voltage of 300 V. However

the electric currents are 64 pA and 45 pA for the needle-ring and UV-lamp ion sources

respectively. Experimental results thus reveal that the integrated FAIMS using the needle-ring ion source can work stably and that it has a better integration property and stronger signal when compared to a UV-lamp ion source.

关键词

Keywords

references

McDANIEL E W, MASON E A. Book Review: The Mobility and Diffusion of Ions in Gases [M]. New York: Wiley, 1973.

PAPANASTASIOU D, WOLLNIK H, RICO G, et al.. Differential mobility separation of ions using a rectangular asymmetric waveform[J]. Journal of Physical Chemistry A, 2008, 112(16): 3638-3645.

TANG F, WANG X H, LIU K, et al.. Ambient negative corona discharge ion source with small line-cylinder electrodes[J]. Opt. Precision Eng., 2009, 17(8): 1953-1957.

李华, 李玉凯, 陈真诚, 等.利用离子风实现后吸式进样与电离集成的离子源[J].光学精密工程, 2015, 23(12): 3405-3413.

LI H, LI Y K, CHENG ZH CH, et al.. Ion source with posterior suck sampling and ionization by ionic wind[J]. Opt. Precision Eng., 2015, 23(12): 3405-3413. (in Chinese)

郭大鹏, 汪永欢, 汪小知, 等.利用芯片式高场非对称波形离子迁移谱技术快速检测苯丙氨酸[J].分析化学, 2016, 44(4): 617-624.

GUO D P, WANG Y H, WANG X ZH, et al.. Rapid determination of phenylalanine by chip-type high-field asymmetric waveform ion mobility spectrometry[J]. Analytical Chemistry, 2016, 44(4): 617-624.(in Chinese)

GUEVREMONT R, PURVES R. Comparison of experimental and calculated peak shapes for three cylindrical geometry FAIMS prototypes of differing electrode diameters[J]. Journal of the American Society for Mass Spectrometry, 2005, 16(3): 349-362.

BORSDORF H, NAZAROV E G, EICEMAN G A. Atmospheric pressure chemical ionization studies of non-polar isomeric hydrocarbons using ion mobility spectrometry and mass spectrometry with different ionization techniques[J]. Journal of the American Society for Mass Spectrometry. 2002;13: 1078-1087.

刘坤, 唐飞, 王晓浩, 等.一种用于高场非对称波形离子迁移谱系统的新型敞开式化学离子源[J].物理化学学报, 2009, 25(8): 1662-1670.

LIU K, TANG F, WANG X H, et al.. Novel chemical ion source for a high-field asymmetric waveform ion mobility spectrometer used under ambient conditions[J]. Acta Physico-Chimica Sinica, 2009, 25(8): 1662-1670. (in Chinese)

刘友江, 陈池来, 孔德义, 等.基于紫外光离子源高场不对称波形离子迁移谱的化学战剂模拟剂检测[J].分析化学, 2014, 42(9): 1259-1263.

LIU Y J, CHENG CH L, KONG D Y, et al.. Detection of chemical warfare agent simulated by UV photoionization high-field asymmetric ion mobility spectrometry[J]. Chinese Journal of Analytical Chemistry, 2014, 42(9): 1259-1263. (in Chinese)

唐飞, 王晓浩, 刘坤, 等.敞开式小型线-筒电极负电晕放电离子源[J].光学精密工程, 2009, 17(8): 1953-1957.

TANG F, WANG X H, LIU K, et al.. Ambient negative corona discharge ion source with small line-cylinder electrodes[J]. Opt. Precision Eng., 2009, 17(8): 1953-1957. (in Chinese)

赵东杰, 刘军, 丁庆行, 等.一种用于平板型FAIMS的电晕放电离化源[J].传感技术学报, 2018, 31(6): 887-890.

ZHAO D J, LIU J, DING Q X, et al.. A corona discharge ionization source for the planar FAIMS[J]. Journal of Sensing Technology, 2018, 31(6): 887-890. (in Chinese)

李华, 韦昌严, 曾德查, 等.针-柱结构敞开式离子源和微型气泵集成系统的放电特性[J].光学精密工程, 2014, 22(6): 1531-1537.

LI H, WEI CH Y, ZENG D CH, et al.. Discharge properties of integrated system of ambient ion source and micro air pump based on needle-to-cylinder structure[J]. Opt. Precision Eng., 2014, 22(6): 1531-1537. (in Chinese)

李华, 郭超群, 蒋林秀, 等.敞开式离子源和微型气泵集成的微型针-柱放电结构芯片设计与实验分析[J].光学精密工程, 2017, 25(6): 1567-1576.

LI H, GUO CH Q, JIANG L X, et al.. Design and experiment analysis for micro needle-cylinder discharge chip integrated by open ion source and micro pump[J]. Opt. Precision Eng., 2017, 25(6): 1567-1576. (in Chinese).

KRYLOV E V, NAZAROV E G, MILLER R A. Differential mobility spectrometer model of operation [J]. International Journal of Mass Spectrometry, 2007, 266(1/2/3): 76-85.

SHVARTSBURG A A, SMITH R D. Ultrahigh-resolution differential ion mobility spectrometry using extended separation times [J]. Analytical Chemistry, 2011, 83(1): 23-29.

CHAVARRIA M A, MATHEOUD A V, MARMILLOD P, et al..High sensitivity field asymmetric ion mobility spectrometer[J]. Review of Scientific Instruments, 2017, 88(3):035115-1-13.

ZENG Y, TANG F, ZHAI Y, et al.. Performance enhancement of high-field asymmetric waveform ion mobility spectrometry by applying differential-RF-driven operation mode[J]. Review of Scientific Instruments, 2017, 88(9):095113-1-10.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

采用针-环离子源的集成式FAIMS系统设计与实验研究