角膜交联仪光学系统的设计与实现

郑田莉; 付威威; 朱海龙

doi:10.3788/OPE.20192706.1286

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角膜交联仪光学系统的设计与实现

生命科学仪器 | 更新时间：2020-08-13

- 角膜交联仪光学系统的设计与实现
- Design and implementation of optical system for corneal cross-linking device
- 光学精密工程 2019年27卷第6期页码：1286-1292
- 作者机构：
  
  中国科学院苏州生物医学工程技术研究所，江苏苏州 215000
- 作者简介：
  
  [ "郑田莉(1994-)，女，陕西延安人，硕士，主要从事医疗仪器光学设计方面的研究与应用。E-mail：tianlizheng@hotmail.com" ]
  付威威(1983-)，男，吉林长春人，研究员，硕士生导师，2009年毕业于吉林大学，主要从事机器视觉与模式识别技术在生物医学领域的创新应用及成果转化。E-mail：fuww@sibet.ac.cn FU Wei-wei, E-mail: fuww@sibet.ac.cn
- 基金信息：
  
  核黄素紫外角膜交联仪研制-STS双创引导项目(KFJ-STS-SCYD-208)
- DOI：10.3788/OPE.20192706.1286
  中图分类号： TH773
- 收稿日期：2018-12-17，
  
  录用日期：2019-1-29，
  
  纸质出版日期：2019-06-15
- 稿件说明：
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郑田莉, 付威威, 朱海龙. 角膜交联仪光学系统的设计与实现[J]. 光学精密工程, 2019,27(6):1286-1292.

Tian-li ZHENG, Wei-wei FU, Hai-long ZHU. Design and implementation of optical system for corneal cross-linking device[J]. Optics and precision engineering, 2019, 27(6): 1286-1292.
郑田莉, 付威威, 朱海龙. 角膜交联仪光学系统的设计与实现[J]. 光学精密工程, 2019,27(6):1286-1292. DOI： 10.3788/OPE.20192706.1286.

Tian-li ZHENG, Wei-wei FU, Hai-long ZHU. Design and implementation of optical system for corneal cross-linking device[J]. Optics and precision engineering, 2019, 27(6): 1286-1292. DOI： 10.3788/OPE.20192706.1286.

摘要

为了对圆锥角膜为代表的角膜扩张类疾病进行安全有效的治疗，减小手术过程中的人工对准误差，设计了一种用于角膜交联手术装置的光学系统。根据角膜交联手术治疗光斑尺寸、均匀性及工作距的要求，基于复眼透镜阵列匀光原理进行了照明系统设计。设计了一种对人眼区域成像，工作距离为175 mm，放大率

=-4.2的红外镜头。最后，搭建了角膜交联装置原理样机，并对所设计的光学系统进行了测试。实验结果表明，紫外照明光路工作距离为65 mm，输出光斑直径为9 mm，均匀度为90.2%，达到了国外同类仪器水平，红外成像光路可以为手术过程中人眼位置的追踪和定位提供清晰、良好的图像。本文设计的角膜交联装置的光学系统具有结构简单、成本低廉、性能良好等特点，可以很好地满足手术需要。

Abstract

To treat corneal dilatation diseases caused by keratoconus safely and effectively and to reduce manual alignment errors during surgery

an optical system for a corneal cross-linking surgical device was designed in this study. First

based on the requirements of corneal cross-linking surgery related to spot size

uniformity

and working distance

an illumination system was designed based on the principle of uniformation of the compound eye lens array. Second

an infrared lens was designed that was imaged by the human eye with a working distance of 175 mm and a magnification

of -4.2. The aforementioned design was then processed

a prototype of the corneal cross-linking device was built

and the designed optical system was tested experimentally. Experimental results show that the UV illumination light path is 65 mm

output spot diameter is 9 mm

and uniformity is 90.2%

which are comparable to those of similar instruments abroad. The infrared imaging light path can provide clear and quality images for tracking and positioning the human eye during a surgical operation. The optical system of the corneal cross-linking device designed in this study has the characteristics of a simple structure; further

it is low cost

exhibits good performance

and can well meet surgical requirements.

关键词

Keywords

references

YUE B Y J T, SUGAR J, SCHRODE K. Histochemical-studies of keratoconus[J]. Current Eye Research , 1988.7(1):81-86.

ANDREANOS K D, HASHEMI K, PETRELLI M, et al .. Keratoconus treatment algorithm[J]. Ophthalmology and Therapy , 2017, 6(2):245-262.

SPOERL E, HUHLE M, SEILER T. Induction of cross-links in corneal tissue[J]. Experimental Eye Research , 1998, 66(1):97-103.

BUEELER M, SPOREL E, SEILER T, et al .. UV collagen cross-linking of the cornea: safety aspects and design of a UV illumination system[J]. SPIE , 2008, 6844.

SUBASINGHE S K, OGBUEHI K C, DIAS G J. Current perspectives on Corneal Collagen Crosslinking (CXL)[J]. Graefe's Archive for Clinical and Experimental Ophthalmology , 2018, 256(8):1363-1384.

李伦, 郝永平, 刁晓蕾, 等.可变焦距的非球面复眼优化及定位技术[J].光子学报, 2018, 47(10):216-226.

LI L, HAO Y P, DIAO X L, et al .. Aspherical compound eye optimization and positioning technology with variable focal length[J]. Acta Photonica Sinica , 2018, 47(10):216-226.(in Chinese)

赵阳, 巩岩.深紫外光刻照明系统光束整形单元的设计[J].光学精密工程, 2011, 19(1):29-34.

ZHAO Y, GONG Y. Design of beam shaping unit for deep ultraviolet lithographic illumination system[J]. Opt. Precision Eng. , 2011, 19(1):29-34.(in Chinese)

肖志涛, 娄世良, 吴骏, 等.立体成像眼底相机光学系统设计[J].光学精密工程, 2018, 26(5):1054-1060.

XIAO ZH T, LOU SH L, WU J, et al .. Design of optical system for stereo imaging fundus camera[J]. Opt. Precision Eng. , 2018, 26(5):1054-1060.(in Chinese)

沈湘衡, 杨亮, 贺庚贤, 等.光电测量设备光学系统的像面照度均匀性检测[J].光学精密工程, 2008, 16(12):2531-2536.

SHEN X H, YANG L, HE G X, et al .. Measurement of image plane illumination non-uniformity of optical system in photoelectric equipment[J]. Opt. Precision Eng. , 2008, 16(12):2531-2536.(in Chinese)

李博, 冯松, 毛军红.在线图像可视铁谱成像系统的像面照度均匀性[J].光学精密工程, 2016, 24(10):2347-2356.

LI B, FENG S, MAO J H, et al .. Illumination uniformity of an imaging system for on-line visual ferrograph[J]. Opt. Precision Eng. , 2016, 24(10):2347-2356.(in Chinese)

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