基于光声谱法的无创血糖在体检测

吕鹏飞; 陆志谦; 何巧芝; 王倩

doi:10.3788/OPE.20192706.1301

您当前的位置：

首页 >

文章列表页 >

基于光声谱法的无创血糖在体检测

生命科学仪器 | 更新时间：2020-08-13

- 基于光声谱法的无创血糖在体检测
- Non-invasive blood glucose in vivo detection based on photoacoustic spectroscopy
- 光学精密工程 2019年27卷第6期页码：1301-1308
- 作者机构：
  
  上海交通大学仪器科学与工程系，上海 200240
- 作者简介：
  
  [ "吕鹏飞(1994-)，男，内蒙古乌兰察布人，硕士研究生，2016年于哈尔滨工业大学测控技术与仪器专业获得学士学位，主要从事无创血糖检测的研究。E-mail：116035910014@sjtu.edu.cn" ]
- 基金信息：
  
  国家自然科学基金资助项目(U1637108);国家自然科学基金资助项目(61873168)
- DOI：10.3788/OPE.20192706.1301
  中图分类号： TH773; R318.6
- 收稿日期：2019-02-27，
  
  录用日期：2019-4-2，
  
  纸质出版日期：2019-06-15
- 稿件说明：
移动端阅览
吕鹏飞, 陆志谦, 何巧芝, 等. 基于光声谱法的无创血糖在体检测[J]. 光学精密工程, 2019,27(6):1301-1308.

Peng-fei LÜ, Zhi-qian LU, Qiao-zhi HE, et al. Non-invasive blood glucose in vivo detection based on photoacoustic spectroscopy[J]. Optics and precision engineering, 2019, 27(6): 1301-1308.
吕鹏飞, 陆志谦, 何巧芝, 等. 基于光声谱法的无创血糖在体检测[J]. 光学精密工程, 2019,27(6):1301-1308. DOI： 10.3788/OPE.20192706.1301.

Peng-fei LÜ, Zhi-qian LU, Qiao-zhi HE, et al. Non-invasive blood glucose in vivo detection based on photoacoustic spectroscopy[J]. Optics and precision engineering, 2019, 27(6): 1301-1308. DOI： 10.3788/OPE.20192706.1301.

摘要

为了实现血糖无创在体检测，解决测量灵敏度低、激励源波动影响大、病患体温干扰严重等难题，本文提出一种基于温度补偿的差动光声测量方法，该方法可以大幅度抑制温度的影响。采用两个相同的光声池分别容纳被测血液和纯水，分别获取测量光声信号和参考光声信号。首先，改变两个光声池的液体温度，测定两路光声信号的温度系数；然后，分别对两路光声信号进行温度补偿和修正，消除温度的影响；最后将两路光声信号进行比值处理，抑制光源强度波动的影响。在此基础上，本文还使用组织工程皮肤安体肤来模拟人体皮肤环境，探究皮肤对激光和光声信号的透过性。测试结果表明，低浓度下葡萄糖光声信号强度和浓度的线性拟合直线的拟合度可以达到0.970 6，证实了这种方法在实际应用中的可行性；模拟皮肤的不同位置对激光的穿透率不同，平均透光率为53.88%，皮肤对光声信号的平均透过率为94.50%。本文的研究结果可为血糖在体无创检测的实现提供有益借鉴。

Abstract

To achieve non-invasive blood glucose in vivo detection

solving common problems such as low measurement sensitivity

large interference of excitation source fluctuation

and serious patient temperature interference is first necessary. In this study

a new method based on temperature compensation for differential photoacoustic measurement was proposed

which can greatly suppress the influence of temperature. Two identical photoacoustic cells were used

one for accommodating the blood to be measured

the other for pure water. Measured and reference photoacoustic signals are respectively obtained. First

the temperature coefficient of the two photoacoustic signals is determined by changing the liquid temperature of the two photoacoustic cells. Then

the error of temperature in the two photoacoustic signals are separately compensated and corrected to eliminate the interference of temperature on the experimental results. Finally

the intensity of one photoacoustic signal is divided by that of the other photoacoustic signal to suppress the influence of laser intensity fluctuation. Based on this procedures the study used tissue engineered skin to simulate a human skin environment and explored the skins permeability to laser and photoacoustic signals. The results show that the

of linear fitting between glucose photoacoustic signal intensity and glucose concentration under a low concentration was 0.970 6

thereby proving the feasibility of this method for use in practical applications. The results also show that the average transmittance of the simulated skin to laser was 53.88%

and the average transmittance of the simulated skin to the photoacoustic signal was 94.50%. The results of this study can provide a useful reference for the noninvasive detection of blood glucose.

关键词

Keywords

references

SINGH V, KRISHNAN S. Voltammetric immunosensor assembled on carbon-pyrenyl nanostructures for clinical diagnosis of type of diabetes[J]. Analytical Chemistry, 2015, 87(5): 2648-2654.

李晓莉, 李成伟.改进的自适应噪声总体集合经验模态分解在光谱信号去噪中的应用[J].光学精密工程, 2016, 24(7): 1754-1762.

LI X L, LI CH W. Application of improved complete ensemble empirical mode decomposition with adaptive noise in spectral signal denoising[J]. Opt. Precision Eng. , 2016, 24(7): 1754-1762. (in Chinese)

徐可欣, 陈小龙, 栗大超, 等.基于微流控和酶比色的微创血糖连续检测仪[J].光学精密工程, 2018, 26(11): 2615-2622.

XU K X, CHEN X L, LI DA CH, et al .. Minimally invasive continuous blood glucose monitor based on microfluidic and enzyme colorimetric technologies[J]. Opt. Precision Eng. , 2018, 26(11): 2615-2622. (in Chinese)

ZHAO S W, TAO W, HE Q Z, et al .. A non-invasive photoacoustic and ultrasonic method for the measurement of glucose solution concentration[J]. AIP Advances , 2017, 7(3): 035313.

BRUEN D, DELANEY C, FLOREA L, et al .. Glucose sensing for diabetes monitoring: recent developments[J]. Sensors , 2017, 17: 1866.

王驰.脉冲激光激发皮肤产生超声波的机理研究[D].天津: 天津大学, 2006. http://cdmd.cnki.com.cn/Article/CDMD-10056-2007043046.htm

WANG CH. Study on Mechanism of Ultrasonic Generated by Pulsed Laser Irradiating on Human Skin [D]. Tianjin: Tianjin University, 2016. (in Chinese)

YAO J J, XIA J, MASLOV K I, et al .. Noninvasive photoacoustic computed tomography of mouse brain metabolism in vivo[J]. NeuroImage , 2013, 64: 257-266.

ZHAO S W, TAO W, HE Q Z, et al .. A new approach to non-invasive blood glucose measurement based on 2 dimension photoacoustic spectrum[J]. Proceeding of IMCCC , 2017: 8298673.

JOO YONG SIM, CHANG-GEUN AHN, EUN-JU JEONG, et al .. In vivo microscopic photoacoustic spectroscopy for non-invasive glucose monitoring invulnerable to skin secretion products[J]. Scientific Reports , 2018, 8: 1059.

CHIARAMONTE D. Blood-component therapy: selection, administration and monitoring[J]. Clinical Techniques in Small Animal Practice , 2004, 19(2): 63-67.

KOTTMANN J, REY J M, SIGRIST M W. Mid-infrared photoacoustic detection of glucose in human skin: towards non-invasive diagnostics[J]. Sensors , 2016, 16(10): E1663.

TAO W, LU Z, HE Q, et al .. Research on the temperature characteristics of the photoacoustic sensor of glucose solution[J]. Sensors , 2018, 18(12): 4323.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

基于光声谱法的无创血糖在体检测初探