用于大功率激光治疗的瞬态喷雾冷却系统

徐建根; 崔锦江; 董宁宁; 曹莉

doi:10.3788/OPE.20192706.1309

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用于大功率激光治疗的瞬态喷雾冷却系统

生命科学仪器 | 更新时间：2020-08-13

- 用于大功率激光治疗的瞬态喷雾冷却系统
- Transient spray cooling system for high-power laser treatment
- 光学精密工程 2019年27卷第6期页码：1309-1317
- 作者机构：
  
  1.中国科学院苏州生物医学工程技术研究所，江苏苏州 215163
  2.复旦大学工程与应用技术研究院，上海 200433
  3.苏州科技城医院，江苏苏州 215163
- 作者简介：
  
  [ "徐建根(1987-)，男，江苏苏州人，助理研究员，2010年、2013年于南京航空航天大学分别获得学士、硕士学位，主要从事医用光学、激光诊疗技术及设备的研究和应用。E-mail：jgxu19871121@163.com" ]
  [ "崔锦江(1981-)，女，吉林省吉林市人，博士，研究员，2004年于长春理工大学获得学士学位，2009年于中国科学院长春光学精密机械与物理研究所获得博士学位，主要从事医用光学技术及设备的研究。E-mail：cuijj@sibet.ac.cn" ]
- 基金信息：
  
  国家重点研发计划资助项目(2017YFB0403802);吉林省与中科院省院合作项目(2018YH0023);吉林省重点科技研发项目(20180201047YY);上海市市科委项目(18441904300)
- DOI：10.3788/OPE.20192706.1309
  中图分类号： TN248.4
- 收稿日期：2018-12-18，
  
  录用日期：2019-1-25，
  
  纸质出版日期：2019-06-15
- 稿件说明：
移动端阅览
徐建根, 崔锦江, 董宁宁, 等. 用于大功率激光治疗的瞬态喷雾冷却系统[J]. 光学精密工程, 2019,27(6):1309-1317.

Jian-gen XU, Jin-jiang CUI, Ning-ning DONG, et al. Transient spray cooling system for high-power laser treatment[J]. Optics and precision engineering, 2019, 27(6): 1309-1317.
徐建根, 崔锦江, 董宁宁, 等. 用于大功率激光治疗的瞬态喷雾冷却系统[J]. 光学精密工程, 2019,27(6):1309-1317. DOI： 10.3788/OPE.20192706.1309.

Jian-gen XU, Jin-jiang CUI, Ning-ning DONG, et al. Transient spray cooling system for high-power laser treatment[J]. Optics and precision engineering, 2019, 27(6): 1309-1317. DOI： 10.3788/OPE.20192706.1309.

摘要

大功率激光治疗过程中，避免表皮及正常组织的热损伤副作用，是保证激光治疗安全性和有效性的关键。本文采用具有高制冷性能的医用134a制冷剂，通过对高压储液罐、密闭传输管路、高速雾化喷射装置以及电子学控制等系统的设计，形成了可与治疗激光不同时序输出、对皮肤和组织进行实时快速冷却的瞬态喷雾冷却系统。通过研究喷洒时间、喷射距离、类皮肤材料温度变化之间的量效关系，验证了装置的冷却效果。实验结果表明，在20~50 ms喷洒时间内可将组织温度降低40~60 ℃。冷却系统的生物兼容性、耐压性、密封性通过了医疗器械注册检验。并联合大功率1 450 nm半导体激光用于面部痤疮的临床治疗，189例轻中度痤疮患者在连续治疗4次后治疗的总有效率达87.3%，未出现皮肤热损伤。该瞬态喷雾冷却系统可与各类激光治疗设备集成应用，提高了现有激光治疗技术的安全性、有效性和治疗范围。

Abstract

During high-power laser treatment

protection of the epidermis and normal tissues from thermal damage is critical to ensure safety and effectiveness of the process. In this investigation

medical 134a cryogen with high cooling performance was used

and a high-pressure storage tank

an airtight transmission line

a high-speed atomized spray device

and an electronic control system were designed as part of a transient spray cooling system combined with laser therapy for different output timings to cool the skin and tissue in real-time. By studying the relationship between the spraying time

jet distance

and temperature changes of materials that are similar to skin

the cooling effect of the device was evaluated. The experimental results show that the tissue temperature can be reduced from 40 ℃ to 60 ℃ in 20 ms to 50 ms. The biological compatibility

pressure resistance

and sealing of the cooling system met the requirements of medical device registration. The system was combined with a high-power 1 450 nm semiconductor laser to treat facial acne in a clinical setting

and the total effective rate for 189 patients with mild-to-moderate acne is 87.3% after four treatments without thermal damage. It is possible to combine the transient spray cooling system with various laser devices to improve the safety

effectiveness

and scope of existing laser treatments.

关键词

Keywords

references

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