应用于眼轴参数测量的光学相干层析系统

马思齐; 巩岩; 李丽; 张艳微

doi:10.3788/OPE.20192706.1318

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应用于眼轴参数测量的光学相干层析系统

生命科学仪器 | 更新时间：2020-08-13

- 应用于眼轴参数测量的光学相干层析系统
- Optical coherence tomography system for measurement of eye axial parameters
- 光学精密工程 2019年27卷第6期页码：1318-1326
- 作者机构：
  
  1.上海大学机电工程与自动化学院，上海 200072
  2.中国科学院苏州生物医学工程技术研究所医用光学室，江苏苏州 215163
- 作者简介：
  
  [ "马思齐(1991-)，女，山东泰安人，2011年于长春理工大学获得学士学位，主要从事光学检测方面的研究。E-mail：13776102187@163.com" ]
  巩岩(1968-)，男，吉林人，研究员，博士生导师，1990年于浙江大学获得学士学位，1998年于中科院长春光机所获得硕士学位，2002年于中科院研究生院获得博士学位，主要从事医用光学、光学系统设计、光机系统集成技术、超分辨显微光学技术等方面的研究。E-mail：gongy@sibet.ac.cn GONG Yan, E-mail: gongy@sibet.ac.cn
- 基金信息：
  
  国家重点研发计划-高端超分辨显微物镜装配技术联合研究项目(2016YFE0110100);中科院科研装备研制-超分辨物镜一体化装配系统研制项目(Y722041202)
- DOI：10.3788/OPE.20192706.1318
  中图分类号： O436.1; R770.4
- 收稿日期：2018-12-21，
  
  录用日期：2019-1-9，
  
  纸质出版日期：2019-06-15
- 稿件说明：
移动端阅览
马思齐, 巩岩, 李丽, 等. 应用于眼轴参数测量的光学相干层析系统[J]. 光学精密工程, 2019,27(6):1318-1326.

Si-qi MA, Yan GONG, Li LI, et al. Optical coherence tomography system for measurement of eye axial parameters[J]. Optics and precision engineering, 2019, 27(6): 1318-1326.
马思齐, 巩岩, 李丽, 等. 应用于眼轴参数测量的光学相干层析系统[J]. 光学精密工程, 2019,27(6):1318-1326. DOI： 10.3788/OPE.20192706.1318.

Si-qi MA, Yan GONG, Li LI, et al. Optical coherence tomography system for measurement of eye axial parameters[J]. Optics and precision engineering, 2019, 27(6): 1318-1326. DOI： 10.3788/OPE.20192706.1318.

摘要

生物测量在眼科疾病的诊断和治疗中越来越重要，对儿童和青少年的眼轴长度进行监测有助于预防和治疗近视及其引发的眼科疾病，眼轴参数的准确测量也是影响眼病患者术后视觉质量的重要因素。为了测量眼轴参数，本文研究了基于时域低相干技术的眼轴测量方法，研制了高精度、非接触式眼轴测量的原理样机，并开展了相应的实验研究。利用低相干干涉技术与长相干干涉测距技术结合的方法，采用时域的机械扫描方式，搭建一套光纤型低相干层析测量系统。通过对标准透镜厚度和镜面间隔的测量实验，重复测量精度优于0.3 μm。最后对鱼眼眼轴参数进行测量，清晰得到鱼眼的角膜、晶状体和视网膜等结构。实验结果表明，该系统的稳定性及重复性均能达到设计要求，可以用于动物眼轴参数的测量。

Abstract

Biometrics is becoming more and more important in the diagnosis and treatment of ophthalmic diseases. Monitoring the axial length of children and adolescents can help prevent and treat myopia

and the ophthalmic diseases that it causes. The accurate measurement of eye axial parameters is an important factor in visual quality that affects postoperative patients with eye diseases. In order to measure the parameters of the eye axis

the eye axis measurement method based on the time domainlow-coherence technique of time domain is presented. The prototype for high-precision and non-contact measurement is developed and the corresponding experiments are conducted. Using a combination of low-coherence interference technique and long coherent interference ranging technology

a fiber-optic low-coherence tomography measurement system is built using time-domain mechanical scanning. The repeatability error of standard lens thickness and mirror spacing measurements is less than 0.3 μm. In the experimental measurement of fish-eye axis parameters

the structure of the cornea

lens

and retina of the fish eye was clearly tested. The stability and repeatability of the system meets the design requirements. The tomographic measurement experiment on fish eyes successfully verified that the system can be used for the measurement of animal eye axis parameters.

关键词

Keywords

references

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