激光散斑血流成像系统中的光源相干性

李宜璋; 杨晖; 李然; 刘宏业; 范彦平; 郑刚; 孔平

doi:10.3788/OPE.20192710.2127

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激光散斑血流成像系统中的光源相干性

现代应用光学 | 更新时间：2020-08-13

- 激光散斑血流成像系统中的光源相干性
- Source coherence in laser speckle blood imaging system
- 光学精密工程 2019年27卷第10期页码：2127-2135
- 作者机构：
  
  1.上海理工大学光电信息与计算机工程学院，上海 200093
  2.上海理工大学医疗器械与食品学院，上海 200093
  3.上海健康医学院上海市分子影像重点实验室，上海 201318
- 作者简介：
  
  [ "李宜璋(1995-)，男，江苏苏州人，博士研究生，2017年于南京邮电大学获得学士学位，主要从事光电精密测试技术方面的研究。E-mail：1332358612@qq.com" ]
  杨晖(1981-)，男，上海人，博士，教授，博士生导师，2003年、2006年、2009年于上海理工大学分别获得学士、硕士、博士学位，主要从事光电精密测试技术、激光测量、颗粒技术等方面的研究。E-mail：yanghui@usst.edu.cn YANG Hui, E-mail:yanghui@usst.edu.cn
- 基金信息：
  
  国家自然科学基金面上项目(11572201)
- DOI：10.3788/OPE.20192710.2127
  中图分类号： TN247; TP391.41
- 收稿日期：2019-03-29，
  
  录用日期：2019-5-20，
  
  纸质出版日期：2019-10-15
- 稿件说明：
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李宜璋, 杨晖, 李然, 等. 激光散斑血流成像系统中的光源相干性[J]. 光学精密工程, 2019,27(10):2127-2135.

Yi-zhang Li, Hui YANG, Ran LI, et al. Source coherence in laser speckle blood imaging system[J]. Optics and precision engineering, 2019, 27(10): 2127-2135.
李宜璋, 杨晖, 李然, 等. 激光散斑血流成像系统中的光源相干性[J]. 光学精密工程, 2019,27(10):2127-2135. DOI： 10.3788/OPE.20192710.2127.

Yi-zhang Li, Hui YANG, Ran LI, et al. Source coherence in laser speckle blood imaging system[J]. Optics and precision engineering, 2019, 27(10): 2127-2135. DOI： 10.3788/OPE.20192710.2127.

摘要

针对激光散斑血流成像系统中光源相干性对散斑衬比的影响进行了研究，提出了一种基于混合遗传算法的散斑图像恢复方案。首先，分析非完全相干光用于激光散斑血流成像系统时的劣势，说明混合遗传算法恢复被低相干性光源破坏的散斑图像的原理；使用对比度与噪声比来衡量由两种光源成像得到的静态白盘散斑图像质量；最后，将算法分别用于静态白盘散斑图像和真实的手背血流检测场景。实验结果表明，相干性较好的单纵模激光器成像得到的散斑图像，较之于相干性较差的半导体激光器成像得到的散斑图像，对比度与噪声比高出67.2%；将算法用于质量较差的散斑图像后，其对比度与噪声比提高了57.7%；将算法用于手背血流检测场景，进行恢复运算后，验证了手指指尖的血流灌注量平均高于手指关节30%的临床事实。将本算法用于激光散斑血流成像系统，可以有效消除非完全相干光给散斑衬比分析造成的影响，获得质量更好的血流图像。本算法的推广使用可以提高激光散斑血流仪器在光源选择方面的灵活性。

Abstract

This study investigated the influence of the light source coherence in a laser speckle blood imaging system on speckle contrast analysis. Therefore

a speckle image restoration scheme based on a hybrid genetic algorithm was proposed. First

the disadvantages of using finite coherent lasers in a laser speckle blood imaging system were analyzed and the principle of a hybrid genetic algorithm used to restore speckle images destroyed by a finite coherent laser was explained. Then

the Contrast to Noise Ratio (CNR) was used to measure the quality of static white disk images from two laser sources. Finally

to verify the effectiveness of the algorithm

it was applied to the speckle image of a disk and the real blood flow detection scene on the back of a hand. Compared with the CNR of the speckle images obtained by a diode laser with low coherence

the CNR of those obtained by a single longitudinal mode laser with good coherence was 67.2% higher. When the algorithm was applied to a speckle image of poor quality

the CNR is improved by 57.7%. When it was applied to the blood flow detection scene on the back of a hand that had undergone a restoration operation

the clinical fact that the blood perfusion index of the fingertip was 30% higher than that of the finger joint was accurately measured. When the algorithm was applied to a laser speckle blood imaging system

the effect of the finite coherent laser on speckle contrast analysis could be effectively eliminated

facilitating the procurement of better blood flow images. Further popularization of this method could improve the flexibility of laser speckle blood flow instruments in laser source selection

which has certain application value.

关键词

Keywords

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